The human Oct-4 gene has three isoforms, Oct-4A, Oct-4B and Oct-4B1, which are thought to be derived from alternative splicing. It remains controversial whether the Oct-4 gene is expressed in cancer cells. Expression of Oct-4A is regulated by two elements, the PE (proximal enhancer) and DE (distal enhancer), but the expression and regulation of Oct-4B are not well known. Here, we firstly report...

A series of carbocyclic analogues of naturally-occurring marine sphingolipid pachastrissamine were prepared and biologically evaluated. The analogues were efficiently synthesized via a tandem enyne/diene-ene metathesis reaction as a key step. We found that the analogue 4b exhibited comparable cytotoxicity and more potent inhibitory activity against sphingosine kinases, compared to pachastrissam...

In this article Figs. 4a and 4b (trajectories taken by the rat when the platform is within initial visual range) appeared as identical. The correct Fig. 4b should have appeared as below: 227

Nodulations of Glycine max L. seedlings by parental Rhizobium japonicum (USDA strain 26) and a tryptophan catabolic mutant (tan 4b, NRRL strain B-14075) were evaluated for effectiveness. Seedlings grown in plastic pouches were compared based on increases in root weight (wt.), nodule volume (vol.) and acetylene-reducing (AR) activity. The tan 4b mutant, which can produce extracellular indol-3yl-...

The hemisynthesis of the title compound, C22H32O2, was carried out through direct acetyl-ation reaction of the naturally occurring diterpene totarol [systematic name: (4bS,8aS)-4b,8,8-trimethyl-1-propan-2-yl-5,6,7,8a,9,10-hexa-hydro-phen-an-thren-2-ol]. The mol-ecule is built up from three fused six membered rings, one saturated and two unsaturated. The central unsaturated ring has a half-chair...

Cyclization and chlorination of 2-amino-5-benzyl-4, 5, 6, 7-tetrahydro hydro thieno [3, 2c] pyridine-3carboxamide yielded (3 a-b). Reaction with different substituted pyridines of [3 a-b] yielded 4a (1-4) and 4b (1-2). However reaction of 3a with different substituted 2-amino phenols yielded 4a (5-6). Further 3a yields 4a (7) & 4a (8) from different substituents like o-phenylene diamine and 4-c...