Megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) is a tyrosine phosphatase expressed in megakaryocytic cells, and causes insulin sensitization when down regulated. Therefore, specific inhibitors of PTP-MEG2 are potential candidates for novel Type 2 Diabetes (T2DM)therapy. In this study, we discovered PTP-MEG2 inhibitors using high throughput and virtual screening (HTS/VS) and structural ...

We are engaged in airborne transmission and epidemiology studies of respiratory pathogens, with particular interest in human parainfluenza virus type 4 (hPIV-4) and other lesser studied viruses. In this paper, hPIV-4 was detected in primary rhesus monkey kidney (PRMK) cells that had been inoculated with nasopharyngeal swab material obtained from a child with a mild upper respiratory tract illne...

ductance of layer. These dependencies showed that hybridization appears when sheet conductance of layer (σ) exceeds some critical value σcr), the magnitude of which changes in wide range and depends on material and plate orientation. For example, for aforementioned hybrid pair A0 SH0 in potassium niobate σcr = 10−3S. If σ < σcr modes are not coupled, i.e. their dispersion curves do not repulse....

Recently we reported that removal of noncovalently bonded protein from glutenin resulted in decreased viscoelasticity. In that study, two glutenin fractions were isolated by successive gel filtration of glutenin on Sephadex G-200 in the solvents acetic acid-guanidine hydrochloride (GuHCl)-cetyltrimethylammonium bromide (AGC) and sodium dodecyl sulfate (SDS). This note reports the S20,W values o...

introduction: hepatitis c virus (hcv) is the major cause of acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma worldwide. because of increasing number of infected patients throughout the world, various studies are concentrated on development of high quality diagnostic tests and genotyping in various regions of the world. methods: in this study, we used rt-pcr to isolate and a...

purified reovirus type 3 (strain dearing) was treated with monoclonal anti-?l antibody conjugated to ferritin and examined in the electron microscope. virion associated ferritin molecules corresponding to locations of the ?l protein were observed. electron microsocpy of thin sections of these preparations revealed that ferritin conjugates were localized at the vertices of the viral icosahedron....