The title compound, C(10)H(7)Cl(2)NO, features a planar mol-ecule, excluding the methyl H atoms [maximum deviation = 0.0385 (1) Å]. The crystal packing is stabilized by π-π stacking inter-actions across inversion centres [centroid-to-centroid distance = 3.736 (3) Å].

2,2'-disubstitutedamino-4-4'-bis-pyrimidines (3a-m) have been prepared by linking 2,4-dichloro-6-methyl-5-nitropyrimidine (1) with several diamines and subsequent reaction with suitable amines. some of these compounds (3c and 3j) which were reduced catalitically, on treatment with nitrous acid, urea in pyridine, and boiling thionyl chloride gave the corresponding bistriazolopyrimidin ...

An enzyme inhibiton method for the determination of serum levels of DDMP is described. This has proved to be a simple, practical, and reliable method for the clinical monitoring of patients.

The toxicology of a potentially useful antitumor agent, 2,4-diamino-5-adamantyl-6-methylpyrimidine (DAMP), and its ethanesulfonate salt has been studied in beagle dogs after 1 to 20 doses. Two types of toxicity could be discerned: the acute central nervous system toxicity manifested by vomiting, convulsions, and minor hypothermia; and the antiproliferative toxicity, similar to that of other fol...

The title compound, C(14)H(9)BrCl(2)N(2)O, was synthesized by the reaction of 2,4-dichloro-benzaldehyde with an equimolar quantity of 3-bromo-benzohydrazide in methanol. The mol-ecule displays an E configuration about the C=N bond. The dihedral angle between the two benzene rings is 5.3 (2)°. In the crystal structure, mol-ecules are linked through inter-molecular N-H⋯O and C-H⋯O hydrogen bonds,...

The title compound, C(14)H(9)BrCl(2)N(2)O(2), was prepared by the reaction of 3,5-dichloro-2-hydroxy-benzaldehyde and 3-bromo-benzohydrazide in methanol. The dihedral angle between the two benzene rings is 13.0 (2)°. An intra-molecular O-H⋯N hydrogen bond is observed. The mol-ecules are linked into chains along the c axis by inter-molecular N-H⋯O hydrogen bonds.

the biliary excretion and blood/plasma ratios of four novel 5-bromo-6-alkoxy- 5,6-dihydro prodrugs to s-ethyl-2'-deoxyuridine (edu) including (-)-trans-(5s, 6s)-s-bromo-s-ethyl-6-methoxy-s, 6-dihydro-2'-deoxyuridine (bmedu), (+ )-trans( sr, 6r)-s-bromo-s-ethyl-6-ethoxy-s, 6-deoxyuridine (beedu), (+ )-trans-(sr, 6r)-5-bromo-5-ethyl-6-ethoxy -s, 6-dihydro-s '-o-valeryl-2 ':.de...