Actinic keratoses are rough, scaly lesions that commonly occur on sun-exposed areas of the skin. The prevalence of the condition increases with age. Actinic keratoses are thought to be carcinomas in situ, which can progress to squamous cell carcinomas. The decision to treat can be based on cosmetic reasons; symptom relief; or, most importantly, the prevention of malignancy and metastasis. Treat...

Fluorouracil (5-FU) is a relatively unique drug in oncology because administration in different doses and schedules results in dramatically different patterns of qualitative toxicity. In the 41 years 5-FU has been available to the clinical oncologist, a wide variety of doses and schedules of this agent have been used. Infusional schedules are associated with less myelosuppression but may have m...

Abstract Background The skin is both a target and potential conduit for the delivery of drugs, but its cornified cell layer resists penetration by most molecules. This study investigated superparamagnetic iron oxide nanoparticles to facilitate transdermal anticancer agents. Results Chemotherapeutic cancer drugs were applied with or without hairless mice, their ability penetrate was assessed usi...

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