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The hypothalamic tuberoinfundibular dopaminergic (TIDA) neurones secrete dopamine, which inhibits prolactin secretion. TIDA neurone numbers are deficient in Ames (df/df) and Snell (dw/dw) dwarf mice, which lack prolactin, growth hormone and thyroid-stimulating hormone. Prolactin therapy initiated before 21 days maintains normal-sized TIDA neurone numbers in df/df mice and, when initiated as ear...

Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 and diffusion coefficient) present significant challenges to diffusion imaging with conventional di...

Thyroid hormone has pleiotropic effects on cochlear development, and genomic variation influences the severity of associated hearing deficits. DW/J-Pou1f1dw/dw mutant mice lack pituitary thyrotropin, which causes severe thyroid hormone deficiency and profound hearing impairment. To assess the genetic complexity of protective effects on hypothyroidism-induced hearing impairment, an F1 intercross...

Nutritional value of freshwater mesozooplankton, fatty acid (FA) and amino acid (AA) compositions were determined in the middle of each season for a one-year period from May 2009 to February 2010 in Hanna Dam Lake, Isfahan, Iran. FA and AA composition significantly (P < 0.05) varied in relation to the seasonal changes of water quality, phytoplankton and zooplankton community. The content of sat...

The organochlorine compounds (OCs) contamination was studied in different tissues of the adult Black Sea turbot (BST) from natural spawning populations of 2008, 2009 and 2013 in the South-Western shelf off Crimea, the Black Sea. Total lipids, six congeners of polychlorinated biphenyl (CB 28, 52, 101, 138, 153, 180) and organochlorine pesticide p,p’DDT including its metabolites p,p’DDE and p,p’D...

Objective(s) Fatty acid is amide hydrolase which reduce endogenous anandamide. Transient receptor potential vanilloid-1 (TRPV1) channels have been reported to have a role in the modulation of anxiety-like behaviors in rodents. In the present study, the effects of either endocannabinoid system or TRPV1 channels and their possible interaction on anxiety-like behaviors of the rats were explored. ...

UNLABELLED Systemic sclerosis (SSc) is a rare, autoimmune disease characterized by cutaneous and visceral fibrosis. Interleukin- 6 (IL-6) is involved in the pathogenesis of many immune-mediated diseases. IL-6 plays an important role in the initiation and promotion of fibrosis. The polymorphism in the position -174 (G/C) of the promoter region of the IL-6 gene (IL-6pr) may alter the expression o...

A Data Warehouse (DW) is a repository of information retrieved from multiple, possibly heterogeneous, autonomous, distributed databases and other information sources for the purpose of complex querying, analysis and decision support. Data in the DW are selectively collected from the sources, processed in order to resolve inconsistencies, and integrated in advance (at design time) before data lo...