Novel substituted 2,3-dihydrobenzofuran-7-carboxamide (DHBF-7-carboxamide) and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide (DHBF-3-one-7-carboxamide) derivatives were synthesized and evaluated as inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). A structure-based design strategy resulted in lead compound 3 (DHBF-7-carboxamide; IC50 = 9.45 μM). To facilitate synthetically feasible derivativ...

Here we describe the use of a new open-source software package and a Raspberry Pi(®) computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater(®), used in the treatment of tuberculosis - and its reduced derivative piperazine-2-carboxamide.

The ring opening of phthalimide derivatives viz N-cyclopentylphthalimide (1a), N-benzylphthalimide (1b), Nprop-2-ynylphthalimide (1c), 1-phthloylamino-3-[4-(2-methoxyphenyl)-piperizin-1-yl]-propane(1d) and 1­ phthloylamino-4-[4-(2-methoxyphenyl)-piperizin-1-yl]-butane (1e) was accomplished using benzylamine in dimethylformamide (DMF) at room temperature to afford the corresponding carboxamides:...

In the title compound, [Cd(NO(3))(2)(C(5)H(5)N(3)O)(2)(H(2)O)(2)]·2C(5)H(5)N(3)O, the Cd(II) cation is located on a twofold rotation axis and is coordinated by two pyrazine-2-carboxamide ligands and two water mol-ecules and chelated by two nitrate anions in a distorted square-anti-prismatic geometry. Extensive inter-molecular N-H⋯O, N-H⋯N, O-H⋯O and O-H⋯N hydrogen bonds, as well as weak inter-m...

In the title compound, C(16)H(12)N(2)O(2), both terminal benzene rings are located at the same side of the central epoxide ring, showing a cis conformation. The epoxide ring makes dihedral angles of 76.59 (10) and 62.40 (11)° with the phenyl and cyano-phenyl rings, respectively. Inter-molecular N-H⋯O and weak C-H⋯O hydrogen bonding is present in the crystal structure.

The title compound, C(11)H(12)N(2)O(2), shows an S configuration, in which the pyrrolidinone ring is twisted with respect to the phenyl plane, making a dihedral angle of 70.73 (7)°. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, building up a layer parallel to (001).