The ETS protein Spi-1/Pu.1 plays a pivotal and widespread role throughout hematopoiesis in many species. This study describes the identification, characterization, and functional analysis of a new zebrafish spi transcription factor spi-1– like (spi-1l) that is expressed in primitive myeloid cells, erythro-myelo progenitor cells, and in the adult kidney. Spi-1l functions genetically downstream o...

In order to define a modern approach for Software Process Improvement (SPI), the SPI Manifesto was developed, discussed, and finalized at the 16 EuroSPI Conference in 2009 in Alcala, Spain. The common understanding gained during the discussion and usage of the manifesto formed a nucleus from which the new ISO/IEC 33014[ISO01] was derived. In parallel to the development of the SPI Manifesto, the...

The evolution of bacterial pathogenicity, heavily influenced by horizontal gene transfer, provides new virulence factors and regulatory connections that alter bacterial phenotypes. Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2) are chromosomal regions that were acquired at different evolutionary times and are essential for Salmonella virulence. In the intestine of mammalian hosts, S...

We investigated the phylogenetic distribution of the SPI-1 and SPI-2 pathogenicity islands in Salmonella spp. SPI-1 was present in representatives of all eight subspecific groups, but no SPI-2-hybridizing sequences were detected in group V (S. bongori). Our data suggest that SPI-2 was acquired by S. enterica after its split from S. bongori.

This study used the standardized precipitation index (SPI) and runoff (SRI) to analyze dry humid conditions in hill-country catchment area of Laborec River (Slovakia) over a period 50 years (1970–2019). Analysis SPI SRI various time scales showed occurrence wet periods (index > 1.0) that were associated with exceeding long-term norm, below −1.0), which result small amounts precipitation. cor...

BACKGROUND This study evaluated two doses of etoricoxib (60 and 90 mg) vs. naproxen 1000 mg in subjects with ankylosing spondylitis (AS). METHODS This was a 2-part, double-blind, active comparator-controlled non-inferiority study in subjects ≥18 years of age with AS. In Part I, subjects were randomized to naproxen 1000 mg; etoricoxib 60 mg, and 90 mg. In Part II, naproxen and etoricoxib 90 mg...

The Ets transcription factor Spi-C, expressed in B cells and macrophages, is closely related to PU.1 and has the ability to recognize the same DNA consensus sequence. However, the function of Spi-C has yet to be determined. The purpose of this study is to further examine Spi-C activity in B cell development. First, using retroviral vectors to infect PU.1(-/-) fetal liver progenitors, Spi-C was ...

In the early writing on software process improvement (SPI), it was suggested that the group of people responsible for designing and implementing the SPI system should apply the principles of SPI on themselves, making sure their own processes were no less mature than the processes they were trying to improve. Looking at maturity level theory from various literature sources, it seems reasonable t...

The effect of the length of record on the standardized precipitation index (SPI) calculation was investigated by examining correlation coefficients, the index of agreement, and the consistency of dry/wet event categories between SPI values derived from different precipitation record lengths. The effect was also illustrated by comparing SPI values derived from different lengths of record in some...

Managing a successful Software Process Improvement (SPI) is a challenging issue that many software companies face today. Many companies have invested huge amount of money in improving their software processes. This can be confirmed through several papers that present the results of SPI programs. However, as pointed out by the literature, many of these programs have encountered difficulties to a...