Three new lignans, sambucunol A (8) ((+)-erythro-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(4-hydroxy-3-methoxycinnamoyloxypropanyl)-2-hydroxyphenoxy]-1, 3-propanediol), sambucunol B (9) ((+)-threo-1-(4-hydroxyl-3-methoxyphenyl)-2-[4-(4-hydroxy-3-methoxy-cinnamoyloxy propanyl)-2-hydroxyphenoxy]-1, 3-propanediol) and buddlenol G (10) (2-{4-[2, 3-dihydro-3-hydroxymethyl-7-hydroxy-5-(4-hydroxy-3-methoxyc...

The reactions of 1,4-bis(n-alkyloxy)-2,5-bis(3,2?:6?,3?'-terpyridin-4?-yl)benzene ligands with methoxy (1), ethoxy (2), n-propoxy (3), n-butyloxy (4), n-pentyloxy (5), n-hexyloxy (6), n-heptyloxy (7) and n-octyloxy (8) substituents [Cu(hfacac)2].H2O (Hhfacac = 1,1,1,5,5,5-hexafluoropentane-2,4-dione) under conditions crystal growth by layering have been investigated using different combinations...

A series of 2,6-disubstituted pyridine derivatives were prepared from 2,6-diacetylpyridine or 2,6dicarbonyl pyridine dichloride as starting materials. Reaction of 2,6-diacetylpyridine 1 with hydroxylamine hydrochloride or different aromatic aldehydes afforded the corresponding 2,6-diacetylpyridine dioxime and 2,6-bis-[β -(2-thienyl)acryloyl]pyridine derivatives 2 and 3, respectively. Additional...

The asymmetric unit of the title co-crystal, 2C(13)H(10)N(2)O(3)·C(14)H(14)N(4)O(2), comprises one mol-ecule of 2-(4-hydroxy-phenyl-diazen-yl)benzoic acid and half of an N,N'-bis-(4-pyridylmeth-yl)oxamide mol-ecule as the latter is disposed about an inversion centre. The most notable feature of the crystal structure is the formation of supra-molecular chains arising from hydr-oxy-pyridine O-H⋯N...

The electronic structure of a family of bis(imino)pyridine iron dihalide, monohalide, and neutral ligand compounds has been investigated by spectroscopic and computational methods. The metrical parameters combined with Mössbauer spectroscopic and magnetic data for ((i)PrPDI)FeCl(2) ((i)PrPDI = 2,6-(2,6-(i)Pr(2)C(6)H(3)N=CMe)(2)C(5)H(3)N) established a high-spin ferrous center ligated by a neutr...

To reduce volumetric shrinkage of the commercially available polymeric dental composite during curing reaction, (2,2-bis [4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propane) (bis-GMA) derivatives, i.e., (2,2-bis[3-methyl, 4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propan) (DMBis-GMA) and (2,2bis[3,5-dimethyl, 4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propane) (TMBis-GMA) were sy...

D-Amino acid oxidase (DAAO) catalyzes the oxidation of d-amino acids including d-serine, a coagonist of the N-methyl-d-aspartate receptor. We identified a series of 4-hydroxypyridazin-3(2H)-one derivatives as novel DAAO inhibitors with high potency and substantial cell permeability using fragment-based drug design. Comparisons of complex structures deposited in the Protein Data Bank as well as ...