The point-counterpoint articles in the September issue of Diabetes Care (1,2) raise several interesting issues on our understanding of insulin resistance, homeostasis model assessment (HOMA), and the future of measurement shortcuts for insulin resistance and secretion. McAuley et al. (1) provide an overview of methods to assess insulin sensitivity and secretion. The conditional nature of the ti...

BACKGROUND Metabolic Syndrome (MS) is prevalant in China, especially according to the pediatric obesity group. Based on the MS-CHN2012 definition for Chinese children and adolescents the need to explore and establish a convienent MS screening become imminent. This study aims to investigate the optimal cut-off values, compare the accuracy for the (TriGlycerides (TG) to High-Density Lipoprotein C...

Results For the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r=0.64) compared with the HOMA-IR (r=-0.56); p<0.0001. In the ROC analysis, compared with the HOMA-IR, the HOMA-AD showed higher values of the AUC for the identification of IR based on the clamp test (AUC: 0.844 vs. AUC: 0.804) and on the metabolic syndrome (AUC: 0.703 vs. AUC: 0.689), resp...

Background: Insulin resistance is a major cause for developing type 2 diabetes. However, simultaneously pancreatic beta-cell dysfunction must coexist in clinical occurrence of diabetes (T2D). Hence, knowledge regarding residual function and degree insulin required while treating diabetic patients. Aims Objectives: The present study was done to estimate (homeostatic model assessment - HOMA-IR) f...

OBJECTIVE To determine the effects of placebo vs an encapsulated supplement of fruit and vegetable juice concentrate (FVJC) on serum β-carotene levels, insulin resistance, adiposity, and subclinical inflammation in boys. STUDY DESIGN Thirty age-matched prepubertal boys (9 lean and 21 overweight (OW); age range, 6-10 years) were studied. All participants received nutrition counseling and were ...

Background: Chronic HBV infection has a continuous effect on blood sugar and phospholipid metabolism. Metabolic syndrome (MS) insulin resistance (IR) are the main risk factor leading to diabetes cardiovascular disease. At present, relationship between chronic MS was still controversial. Objective: To explore correlation hepatitis B virus (HBV) status, level of surface antigen-anti...

Background and Aim: One-third of NAFLD patients are non-obese. However, there is scant data on pharmacotherapy in non-obese NAFLD. Hence, we explored the efficacy safety Saroglitazar (PPAR Alpha agonist) with Methods: Non-obese (BMI <25kg/m2) elevated ALT >50 U/L were openly randomised (1:1) to receive saroglitazar (4mg/day) lifestyle interventions (Group A) or alone B) for 6-months. Primary ou...

BACKGROUND There are few studies that investigated the correlation between insulin resistance (IR) and the coronary artery remodeling. The aim of the study is to investigate the association of IR measured by homeostasis model assessment of insulin resistance (HOMA-IR) and coronary artery remodeling evaluated by intravascular ultrasound (IVUS). METHODS A total of 298 consecutive patients who r...