Inhibiting NAD biosynthesis by blocking the function of nicotinamide phosphoribosyl transferase (NAMPT) is an attractive therapeutic strategy for targeting tumor metabolism. However, the development of drug resistance commonly limits the efficacy of cancer therapeutics. This study identifies mutations in NAMPT that confer resistance to a novel NAMPT inhibitor, GNE-618, in cell culture and in vi...

Göktürklerin hükmü altına girmek istemeyen Avarlar, batıya doğru hareket etmişler ve Bizans Devleti’ne elçilerini göndererek, onlarla anlaşma yapmak istediklerini bildirmişlerdir. Devleti’nin ise bu sırada, düşmanları olan Bulgarlara Slavlara karşı kullanabilecekleri bir güce ihtiyaçları bulunmaktaydı. Bu sebeple İmparatoru I. Justinianos (527-565), Avarlar ile imzalamıştır. Anlaşmaya göre, Dev...

Arteriovenous fistulas (AVF) are the preferred for hemodialysis access with suitable (2.0-2.5 mm) veins. AVF maturation has been poor globally and often leads to increased catheter contact time costs. Intermittent compression of upper arm veins may aid in forearm vein dilation pre-surgery assist placement size expectations. This is was a prospective, IRB approved trial. A novel intermittent pne...

Section Editor: Rick A. McPheeters, DO Submission history: Submitted February 20, 2016; Revision received May 21, 2016; Accepted June 7, 2016 Electronically published July 19, 2016 Full text available through open access at http://escholarship.org/uc/uciem_westjem DOI: 10.5811/westjem.2016.6.30142 [West J Emerg Med. 2016;17(5)617-618.] Cooper University Hospital, Department of Emergency Medicin...