BACKGROUND Advanced glycation end products (AGEs), senescent macroprotein derivatives formed during a normal aging process and acceleratedly under diabetic conditions, play a role in atherosclerotic cardiovascular disease. AGEs cause endothelial cell (EC) damage, an initial trigger for atherosclerosis through the interaction with a receptor for AGEs (RAGE). We have previously shown that n-butan...

PURPOSE Experimental autoimmune uveitis (EAU) induced in mice using the retinal antigen interphotoreceptor retinoid binding protein (IRBP) is an animal model for posterior uveitis in humans. However, EAU induced by native IRBP protein or its widely used epitope amino acid residues 1 to 20 of human IRBP (hIRBP1-20) is inconsistent, often showing low scores and incidence. We found an urgent need ...

logical changes including cell shrinkage, membrane bleebing, nuclear breakdown, and DNA fragmentation, and is essential for the maintenance of tissue homeostasis and the elimination of harmful cells. An apoptotic death stimulus activates caspases, the major executioners of this process, either directly or via the activation of the mitochondrial death program. The mitochondria-mediated pathway i...

drug for arthritis for thousands of years in China. ST has been reported to have anti-inflammatory and immunosuppressive properties in vitro and in experimental animals. This study was performed to clarify the role of ST from an antioxidative point of view. In the present study, we examined the effects of ST on scavenging activities of reactive oxygen species (ROS) by means of electron spin res...

In this work, CePO4:Ho3+ nanomaterials are prepared by a productive polyol method which shows the dual mode of behavior in Photoluminescence. The up-conversion spectra at 980 nm excitation display sharp brilliant peak ∼520nm - ∼550nm, ∼630 nm, 670 resulting (5F4,5S2→5I8) and (5F5→5I8) Ho3+ ions, it is also found that sample radiates green red colors. down-conversion peaks show maximum absorptio...

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We are proposing a new method for enhancement of optical imaging of proximal interphalangeal (PIP) joints in humans at skin using optical clearing technique. A set of illuminating laser diodes with the wavelengths 670, 820, and 904 nm were used as a light source. The laser diodes, monochromatic digital CCD camera and specific software allowed for detection of the finger joint image in a transil...

Far red and near infrared (NIR) light promotes wound healing, but the mechanism is poorly understood. Our previous studies using 670 nm light-emitting diode (LED) arrays suggest that cytochrome c oxidase, a photoacceptor in the NIR range, plays an important role in therapeutic photobiomodulation. If this is true, then an irreversible inhibitor of cytochrome c oxidase, potassium cyanide (KCN), s...