A portable body-monitoring system developed by the board uses two detectors, one for whole-body measurements and one for thyroid measurements. It can detect most commonly used gamma-ray emitting nuclides down to levels below those of interest for radiological protection purposes. The system has been used at 11 establishments including hospitals, universities, and research laboratories. Measurem...

Bleomycin is considered to be a useful model compound for studying environmental carcinogenesis, due to its broad spectrum of DNA damaging properties. In addition, bleomycin is a useful antitumor drug because of its cytotoxic properties. To investigate the influence of the antioxidant N-acetylcysteine and its metabolites glutathione and cysteine on bleomycin-induced DNA damage and more importan...

Idiopathic pulmonary fibrosis is a lethal lung fibrotic disease, associated with aging mean survival of 2-5 years and no curative treatment. The GSE4 peptide able to rescue cells from senescence, DNA oxidative damage, inflammation, induces telomerase activity. Here, we investigated the protective effect expression in vitro rat alveolar epithelial (AECs), vivo bleomycin model fibrosis. Bleomycin...

1. The role of platelet-activating factor in the attenuated hypoxic pulmonary vasoconstriction associated with lung injury was evaluated using specific platelet-activating factor antagonists and an isolated perfused lung preparation. 2. Intratracheal bleomycin was administered to rats to produce acute lung injury. Animals received intratracheal saline (control), intratracheal bleomycin or the p...

Mutagen sensitivity, measuring the extent of chromosome damage induced by an in vitro treatment of peripheral lymphocytes with bleomycin, has been associated with an increased risk of various human cancers. Sensitivity to bleomycin appears to have high heritability and is usually considered to reflect individual capacity to repair DNA lesions. Another potential contributor to variation in bleom...

malignant pleural effusion is a common complication in certain malignancies. pleurodesis is the best option most of the time. the purpose of this study was to compare the choice of belomycin with povidone-iodine, which is not only determined by the efficacy of the agent but also by its cost, accessibility, safety, ease of administration and the number of administrations to achieve a complete re...

background: patients with symptomatic malignant pleural effusion (mpe) may gain profit from pleurodesis for relief of dyspnea and in preventing the accumulation of fluid or air in the pleural space. pleurodesis methods are palliative and regard the patient's symptoms and underlying disease condition that are different. the purpose of this study was to assess the efficacy of bleomycin in th...

Bleomycin-induced lung disease is characterized by fibroblast proliferation and pulmonary fibrosis. In these studies, we demonstrate that fibroblasts are relatively resistant to clinically relevant amounts (below 10(-4) U/ml) of bleomycin and that these levels of bleomycin augment fibroblast proliferation in response to various fibroblast growth factors. These observations suggest that one mech...

The 14C activity of [14C]bleomycin bound to DNA in bleomycin-sensitive rat ascites hepatoma cells (AH-66) was 8.7 times higher than in resistant cells (AH-66F) when the cells were incubated with [14C]bleomycin. The difference in permeability to bleomycin was not significant; uptake of [14C]bleomycin by the sensitive cells was only 1.2 times larger than that by the resistant cells, and the radio...

Testicular cancer is the most common cancer among young men of reproductive age. Bleomycin is a frequently used drug for the treatment of several malignancies and is part of the chemotherapy protocols used for testicular cancer; however, side-effects are common. Bleomycin causes an increase in oxidative stress which has been shown to induce apoptosis in cancer cells. Curcumin (diferuloylmethane...