Cross-reactivity of pneumococcal capsular polysaccharides is a key element for formulating pneumococcal vaccines and evaluating vaccine efficacy. This study examined whether 23-valent pneumococcal polysaccharide vaccine (PPSV23), which only contains 6B, can elicit cross-functional immune responses against recently discovered serotypes (6C and 6D), as well as against 6A, in 2 adult age groups.Yo...

BACKGROUND We investigated the immune response to serogroup 6 with the opsonophagocytic killing assay (OPKA) in children aged 12-23 months of age after immunization with the 7-valent pneumococcal conjugate vaccine (PCV7) containing serotype 6B. METHODS Blood samples were obtained from 59 children who had blood sampling for medical examination. Immunization status against PCV7 was confirmed by...

CD11b(+)Ly-6C(hi) cells, including inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs), are important in infectious, autoimmune, and tumor models. However, their role in T cell regulation is controversial. In this article, we show that T cell regulation by IMCs and IDCs is determined by their activation state and is plastic during an immune response. Nonactivated IMCs and IDCs...

In this paper we present near-infrared K−band imaging of a sample of ultra-steep spectrum (USS) radio sources selected at 74 MHz. The dual selection criteria of low frequency and USS means that we should be sensitive to the highest redshift (z > 5) radio galaxies. We have obtained K−band magnitudes for all of the objects in our sample of 26 and discuss the properties of each. There is a pronoun...

In a previous study, we showed that after 6 weeks of streptozotocin-induced diabetes (6D), expression of type 2 ryanodine receptor calcium-release channels (RyR2) did not change significantly in rat hearts. However, the ability of this protein to bind [3H]ryanodine was compromised. Loss in activity therefore resulted from diabetes-induced increases in post-translational modifications on RyR2. I...

In this paper, the third and final of a series, we present completeK− band imaging and some complementary I−band imaging of the filtered 6C* sample. We find no systematic differences between the K − z relation of 6C* radio galaxies and those from complete samples, so the near-infrared properties of luminous radio galaxies are not obviously biased by the additional 6C* radio selection criteria (...

A new member of the mouse Ly-6SF, designated Ly-6I, has been isolated as a gene homologous to a segment of the Ly-6C gene. A single allelic difference in the mature protein sequence was identified, which is similar to other Ly-6SF members. Ly-6I mRNA has been detected in a wide range of tissues and cell lines, and a rabbit polyclonal Ab has been used to determine that Ly-6I protein is present a...

CD11b + Ly-6C hi cells, including inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs), are important in infectious , autoimmune, and tumor models. However, their role in T cell regulation is controversial. In this article, we show that T cell regulation by IMCs and IDCs is determined by their activation state and is plastic during an immune response. Non-activated IMCs and IDC...