background: gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. objective: the aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles gnps with x-rays as a function of nanoparticle size and beam energy and ...

Background: Gold nanoparticles (GNPs) are among the most promising radiosensitive materials in radiotherapy. Studying the effective sensitizing factors such as nanoparticle size, concentration, surface features, radiation energy and cell type can help to optimize the effect and possible clinical application of GNPs in radiation therapy. In this study, the radiation sensitive polymer gel was use...

Hypertrophic pulmonary osteoarthropathy (HPOA), mainly manifested clubbing, is rare in patients with esophageal sarcomatoid carcinoma. We herein describe a 48-year-old Chinese man whose advanced carcinoma was diagnosed while examining his symptoms of HPOA. The patient had no opportunity surgery after surgical evaluation. Chemoradiation, including 5 cycles chemotherapy (Paclitaxel liposome 60 mg...

BACKGROUND The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for treatment of F98 glioma bearing rats. METHODS Carboplatin was administered intracerebrally (i.c.) to F98 glioma bearing rats over 6 days using AlzetTM osm...

BACKGROUND Tumor immune-evasion and associated failure of immunotherapy can potentially be overcome by radiotherapy, which however also has detrimental effects on tumor-infiltrating and circulating lymphocytes (CL). We therefore established a model to simulate the radiation-dose delivered to CL. METHODS A MATLAB-model was established to quantify the CL-dose during SBRT of liver metastases by ...

To characterize the radiation dose distribution in the target volume, various dosimetric indices are required which assist in making a choice of an optimum treatment plan. This study is primarily aimed at the analysis of various radiation dose indices essential for the evaluation of therapeutic plans by employing Intensity Modulated Radiotherapy (IMRT) on head and neck cancer patients. A group ...

AIM The aim of the paper is to examine the relation between the increase of the photon dose in water in the region of electronic disequilibrium - so-called build-up region - and the distance of the bolus from the water surface for the applied parameters of X-ray beams. MATERIALS AND METHODS PDD measurements were carried out using the plane-parallel ionization chamber Markus in the automatic w...

BACKGROUND Wedge filters are commonly used in radiation oncology for eliminating hot spots and creating a uniform dose distribution in optimizing isodose curves in the target volume for clinical aspects. These are some limited standard physical wedges (15°, 30°, 45°, 60°),or creating an arbitrary wedge angle, like motorized wedge or dynamic wedge,... The new formulation is presented by the comb...