PURPOSE The prodrug cyclophosphamide (CPA) is activated by cytochrome P450 (CYP) enzymes. CPA is one of the corner stones in all cancer treatment. We have studied the effect of repeated doses of CPA given at different time intervals on the mRNA, protein levels, and enzyme activity of CYPs in rats. EXPERIMENTAL DESIGN Two groups of animals (A-75 and A-150) were treated with four doses of CPA (...

lipid oxidation has adverse effect on food deterioration and human health. the antioxidant activity of fennel seed extracts (fse) was evaluated by synthetic antioxidant. its oxidative stability was compared in olive oils in concentrations of bha (75 ppm), bht(75 ppm) and  1:1 bha to bht ratio. peroxide (pv), p-anisidine (av) and totox values were evaluated to assess the extent of oil deteriorat...

Air pollution is becoming increasingly serious along with social and economic development in the southwest of China. The distribution characteristics particle matter (PM) were studied Chengdu from 2016 to 2017, changes PM bearing water-soluble ions heavy metals secondary analyzed during haze episode. results showed that at different levels, more likely be enriched fine particles may used as a t...

The 440 fertile eggs, in a completely randomized design were divided into 11 treatments with four replicates and 10 eggs per each replicate. Treatments including: (T1; control; without injection), (T2; injected with 0.3 ml saline 9.0%; sham control), (T3, T4 and T5) 25, 75, 125 ppm Fe-Nano, (T6, T7 and T8) 50, 100, 150 ppm Fe-Nano-Alimet chelate, (T9, T10 and T11) 50, 100, 150 ppm Fe-Aliment ch...

line g11867 was first introduced in iran together with 206 other white, chitti and red beans lines through ciat, and was tested in different breeding experiments from 1992 to 1999. it was selected as a superior line in all experiments. in 2001 this line was evaluated with other six lines for drought tolerance, and it was found to be more tolerant than cv. daneshkadeh the check cultivar. line g1...

Field assessment of integrated management BT cotton pests was carried out in two consecutive seasons; 2016/2017 and 2017/2018 the experimental research farm Kassala University, Sudan. Four insecticides (imidacloprid, abamectin, profenofos, lufenuron) from different chemical groups with a mode action three levels (43.81 kgha-1, 87.62 131.43 kgha-1) soil-applied nitrogen were tested IPM package. ...