The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status, and a regulator of energy balance at both the cellular and whole body levels. Although ubiquitously expressed, its function is best understood in skeletal muscle. AMPK contains sites that reversibly bind AMP or ATP, with an increase in cellular AMP:ATP ratio (signalling a fall in cellular energy status) switching on ...

It is still an open question in parallel discrete event simulation what conditions influence the performance of parallel simulation paradigms. We have developed a simulation environment based on asynchronous cellular automata that facilitates basic research into the concepts of discrete event simulation and parallel discrete event simulation, such as the Time Warp paradigm. We address the trans...

Various feature descriptions are being employed in logic program ming languages and constrained based grammar formalisms The com mon notational primitive of these descriptions are functional attributes called features The descriptions considered in this paper are the possi bly quanti ed rst order formulae obtained from a signature of binary and unary predicates called features and sorts respect...

Du point de vtte sociologique, un nouveau palier a 6t6 franchi dans l'intdgration de l 'Europe, alors qu'ailleurs on assiste ~l la r6surgence des nutionalismts. A lu conscience de plus eu plus nette tie la dimensicm mondialt des grands ddfis posds 'a l 'humanit6 s 'oppose une relent6 de plus en plus aigue de reconstruire les identit6s nationales. Or, comme I'a si bitn (lit Hag~gt, "les langues ...

Twenty-five patients undergoing elective intraabdominal surgery received either 1 or 2 g of ampicillin together with 1 g of sulbactam intravenously before surgery. The peritoneal levels of the agent were measured. Both compounds penetrated peritoneal fluid readily; the mean percentage of penetration by ampicillin was 92%; that of sulbactam was 96%. After 1 g of each agent, the peritoneal levels...

While firms have frequently been conceptualized as configurations of choices, the evolution of configurations has not received much attention. We start to develop a typology of evolutionary patterns by describing two developmental paths. Patch-by-patch development is characterized by managers’ sequential creation and elaboration of strategic themes, whereas thin-to-thick development consists of...

Much work has been done recently on the design of a temporal extension to SQL-92, called TSQL2. Similar work is being done to add temporality to the forthcoming SLQ3 standard. Still, TSQL2 is based on the relational model, which is hardly adequate for conceptual modeling of any but the simplest applications. This paper presents a temporal conceptual model, called TERC+, that can be used for dev...

many who have been studying artistic products and the creative impulse that no glib formula can be stated on the basis of a superficial examination, even though of hundreds of free drawings. Joanna Field gives an answer to those who are constantly criticizing psychoanalysis for lack of integrative functions or any philosophic approach to life. She has for the first time, as far as I know, put i...

In 1601, the British ship captain James Lancaster tested what was then a little known innovation in naval dietary practice when he set sail for India with a fleet of four ships. While the crew of three of his ships followed their usual diets, all of the men on the fourth were required to consume a teaspoon of lemon juice three times a day. The utility of this innovation was irrefutable. By half...

Consider an embedding of a graph G in a surface S (map). Assume that the difference splits into connected components (countries), each one homeomorphic to an open disk. (It follows from this assumption that graph G must be connected). Introduce a graph G∗ dual to G realizing the neighbor relations among countries. The graphs G and G∗ have the same set of edges. More precisely, there is a natura...