life-changing complications in virtually every system of the body. Several candidate mechanisms contributing to diabetic complications have been proposed. These mechanisms are accepted widely and include the polyol pathway and glycation. Furthermore, the hyperaggregability of platelets, as well as their hypercoagulability in diabetic patients has also been reported. We previously reported the e...

Abstract Introduction Angioleiomyoma is an unusual, benign tumour originating from the tunica media of blood vessels. They commonly occur in face, neck and lower limb. It rarely found hand not considered differential diagnoses painful subcutaneous tumours. Case Report We present a case 40-year-old man with several month history slow growing lump on his right middle finger. He complained pain di...

9 Running title: Surface binding mutants of LT 10 11 12 Benjamin Mudrak 1 , Daniel L. Rodriguez 2 , and Meta J. Kuehn 1,2* 13 Departments of Molecular Genetics and Microbiology 1 and Biochemistry 2 14 Duke University Medical Center, Durham, NC 27710 15 16 17 18 19 20 21 * To whom correspondence should be addressed: Tel. 919-684-2545; Fax 919-684-8885; 22 E-mail: [email protected] 23 Copyr...

GRK AND β-ARRESTIN MEDIATED DESENSITIZATION OF THE ANGIOTENSIN II TYPE 1A RECEPTOR ELUCIDATED BY DIACYLGLYCEROL DYNAMICS Jonathan D. Violin, Scott M. DeWire, William G. Barnes, and Robert J. Lefkowitz Department of Medicine and Biochemistry, Duke University Medical Center, and Howard Hughes Medical Institute. * These authors contributed equally to this work. Running Title: Receptor Desensitizat...

PI3K/Akt/mTOR-addicted lymphomas Running Title: Dual inhibition of PI3K and mTOR in PEL Aadra P. Bhatt*, Prasanna M. Bhende*, Sang-Hoon Sin, Debasmita Roy, Dirk P. Dittmer and Blossom Damania^. *A.P.B. and P.M.B. contributed equally to this study. Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 2759...

Sequential learning from multiple tutors and serial retuning of auditory neurons in a brain area important to birdsong learning Yoko Yazaki-Sugiyama and Richard Mooney* Department of Neurobiology Duke University School of Medicine Running head: Sequential learning and LMAN tuning Text: 55 pages, including figure legends, references and tables Abstract: 249 words Introduction: 512 words Discussi...

The molecular mechanism underlying Akt activation in zinc-induced cardioprotection 1 SungRyul Lee, Guillaume Chanoit, Rachel McIntosh, David A. Zvara, Zhelong Xu 2 Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 3 27599 4 5 Running head: Zinc and Akt activation 6 7 Correspondence to: 8 Zhelong Xu, MD, PhD 9 Department of Anesthesiology 10 CB# 7010 11 U...