UNLABELLED The purpose of this study was to assess the normal perfusion pattern of the pediatric brain with 99mTc-ethylcysteinate dimer (99mTc-ECD). METHODS Tomographic imaging was performed with a dedicated system with high sensitivity and resolution. Sixteen children, referred for brain imaging in the workup of seizure disorder, were included since they turned out negative after a 1-yr foll...

PURPOSE To observe the effects of Prostaglandin E1 (PGE1) on hematoma, perihematomal tissue and the impairment of neurological function in patients with hypertensive intracerebral hemorrhage (HICH). METHODS A total of 40 patients with HICH were enrolled according to the inclusion criteria and randomly divided into two groups: the control group (n=20) and the PGE1 treatment group (n=20). In ea...

UNLABELLED BACKGROUND Several algorithms from the literature were compared with the original random walk (RW) algorithm for brain perfusion heterogeneity quantification purposes. Algorithms are compared on a set of 210 brain single photon emission computed tomography (SPECT) simulations and 40 patient exams. METHODS Five algorithms were tested on numerical phantoms. The numerical anthropom...

Tc-99m ethyl cysteinate diethylester (ECD) and Tc-99m hexamethyl propylene amine oxime (HMPAO) are commonly used for single-photon emission computed tomography (SPECT) studies of a variety of neurologic disorders. Although these tracers have been very helpful in diagnosing and guiding treatment of neurologic disease, data describing the distribution and laterality of these tracers in normal res...

BACKGROUND Scintigraphic studies have been performed to assess the release, both in vitro and in vivo, of radiotracers from tablet formulations. Four different tracers with differing physicochemical characteristics have been evaluated to assess their suitability as models for drug delivery. METHODS In-vitro disintegration and dissolution studies have been performed at pH 1, 4 and 7. In-vivo s...

Perfusion study should be preoperatively required for the trapping of an internal carotid artery (ICA) in the traumatic pseudoaneurysm in the petrous ICA. A 23-year-old man was admitted with a semicomatose consciousness after a passenger traffic accident. A fracture on the right petrous apex and a pseudoaneurysm in the right petrous ICA was found in the brain computed tomography (CT) angiogram....

We describe a 51-year-old woman with a cerebral infarction that showed transient accumulation of thallium-201. On admission, this lesion was well-enhanced by gadolinium injection and gradually expanded, mimicking a malignant brain tumor. A cerebral angiogram, however, did not indicate the presence of a malignant brain tumor. Ethyl cysteinate dimer single photon computerized tomography showed pe...

UNLABELLED Ictal brain SPECT (IS) findings in neocortical epilepsy (patients without mesiotemporal sclerosis) can be subtle. This study is aimed at assessing how the seizure focus identification was improved by the inclusion of individual IS and interictal brain SPECT (ITS)-MRI image registration as well as performing IS - ITS image subtraction. METHODS The study involved the posthoc analysis...