sternal non-:union: is a severe complication of sternotomy closure following open heart surgeries. healing problems typically occur in 0.3% to 5% of patients. technetium-99m methylene diphosphonate (99mtc-mdp) bone scintigraphy has been used to assess bone non:union: to predict the healing response for proper management.  in this report, we present the case of a marked sternal non:union: follow...

sternal non-union is a severe complication of sternotomy closure following open heart surgeries. healing problems typically occur in 0.3% to 5% of patients. technetium-99m methylene diphosphonate (99mtc-mdp) bone scintigraphy has been used to assess bone nonunion to predict the healing response for proper management.  in this report, we present the case of a marked sternal nonunion following...

OBJECTIVES: Conventional imaging methods are excellent for the morphological characterization of the consequences of osteonecrosis; however, only specialized techniques have been considered useful for obtaining functional information. To explore the affinity of radiotracers for severely devascularized bone, a new mouse model of isolated femur implanted in a subcutaneous abdominal pocket was dev...

In the present study we evaluated the binding of the radiopharmaceuticals sodium pertechnetate (Na 99mTcO4), methylenediphosphonic acid (99mTc-MDP) and glucoheptonate acid (99mTc-GHA) to blood elements using centrifugation and radioautographic techniques. Heparinized blood was incubated with the labelled compounds for 0, 1, 2, 3, 4, 6 and 24 h. Plasma (P) and blood cells (BC) were isolated and ...

In spite of very high sensitivity, bone scan is quite nonspecific in evaluation of bony lesions. In interpretation of bone scan special attention to patient’s clinical presentation and correlation with other lab and imaging modalities should be paid. In this report a patient with Erdheim Chester disease a rare and unusual form of lipidosis is presented and the pattern of 99mTc-MDP bone sc...

Since 1961 bone turnover has been examined using various radio-labeled substances. In 1971 bone scintigraphy was performed the first time using modern 99mTc-labeled polyphosphonates, e.g. 99mTc-hydroxyethylenephosphonate(HDP) or 99mTc-methoxyethylenephosphonate (MDP). After intravenous injection, these radiopharmaceuticals are adsorbed at the bone surface within some hours. The amount of adsorp...

Radiopharmaceuticals used in standard nuclear medicine for patients with breast cancer are a well-known source of ionizing radiation, emitating gamma-photon particles: tumorotroponin cationic complexes such as 99mTc-Sestamibi/ Tetrofosmin (MIBI/TF); radiolabelled somatostatin analogues 111In-Ocrteoscan/99mTc-Tektrotyd; 99mTc-MDP; 99mTc-Nanocoll and etc. The intensive tracer uptake of the differ...

UNLABELLED The constant-volume urinary bladder model in the standard MIRD Pamphlet No. 5 (Revised) phantom has recognized limitations. Various investigators have developed detailed models incorporating more physiologically realistic features, such as expanding bladder contents and residual volume, and variable urinary input rate, initial volume and first void time. We have reviewed these publis...

Introduction: Extraosseous accumulation of 99mTc – methylene diphosphonate (MDP) may be due to neoplastic, dystrophic, hormonal, inflammatory, ischemic, traumatic or excretory disorders. 99mTc-MDP incidental thyroid uptake is not frequent and is possibly caused by the presence of dystrophic or metastatic calcification, biopsy procedure and presence of beni...

the aim of this study was to assess the value of 99mtc-hexakis-2-methoxyisobutylisonitrile (mibi) scintigraphy in patients with clinical and radiologic features of primary or metastatic musculoskeletal tumors. methods: the scintigraphic findings for 84 patients were compared with the surgical and histologic findings. each patient underwent three-phase bone scan with 99mtc-methylene diphosphonat...