BACKGROUND HLA typing analysis is important in renal transplant patients. OBJECTIVES We made a plan to determine the most frequent HLA antigens in Iranian kidney transplant patients. PATIENTS AND METHODS In a retrospective cross sectional study, HLA patterns were defined in 512 kidney transplant recipients (67% male and 33% female) from different transplant centers of Tehran, Iran between 2...

Abstract Background In the present study, detection, characterization and virulence analysis of a field collected nucleopolyhedrovirus isolated from cotton leafworm, Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae) was carried out. The obtained isolate, named SpliNPV-YW, diseased S. larvae in El-Menoufia governorate, Egypt. Results Transmission electron microscopy showed presence typical...

Syngeneic graft-versus-host disease (sGVHD) has been described after hematopoietic cell transplantation (HCT) but remains poorly defined. We retrospectively reviewed adult syngeneic HCTs at our center (1980-2002) for sGVHD to investigate incidence, morbidity, and risk factors with a primary focus on parity. Among 119 transplantations, there were 21 cases of biopsy-proven sGVHD. The cumulative i...

Oligoribonucleotides with specific sequences derived from the satellite RNA of tobacco ringspot virus undergo autolytic cleavage at the CpA phosphodiester that is the junction between unit sequences of multimeric satellite RNA. Buzayan et al. (Nucleic Acids Res., 16, 4009-4023 (1988)) showed that an oligoribonucleotide with 97 satellite RNA-derived nucleotide residues self-cleaved with greatly ...

where ρdos(ν) is the density of states of phonons at frequency ν and other parameters are explained in the original paper. The values of γr used in the paper were based on the experimental results. Therefore, the error in Eq. (A26) does not affect any conclusions and results of the paper. The derivation of this expression follows Carmichael (Ref. 1, Chap. 1.3). Starting with the equations for c...

We have used photo-crosslinking to investigate the structure and dynamics of four-way junction hairpin ribozyme constructs. Four phenylazide photo-crosslinkers were coupled to 2'-NH2-modified U+2 in the substrate and irradiated at different Mg2+ concentrations and temperatures. Consistent with the role of divalent metal ions in hairpin ribozyme folding, we observed more interdomain crosslinks i...

The HLA class I/II alleles and the tumor necrosis factor (TNFA) locus are closely linked in the MHC complex. We have characterized the causative factor VIII mutation, HLA alleles as well as 4 polymorphisms ( 827C>T, 308G>A, 238A>G, and 670A>G) in the TNFA gene in 164 patients (124 severe, 26 moderate, and 14 mild) in 78 families with hemophilia A enrolled in the Malmö International Brother Stud...