Plectin is a major component of the cytoskeleton and links the intermediate filament system to hemidesmosomes by binding to the integrin beta4 subunit. Previously, a binding site for beta4 was mapped on the actin-binding domain (ABD) of plectin and binding of beta4 and F-actin to plectin was shown to be mutually exclusive. Here we show that only the ABDs of plectin and dystonin bind to beta4, w...

Assurance Based Development (ABD) is a novel approach to the synergistic construction of critical software systems and their assurance arguments. In ABD, the need for assurance drives a unique process synthesis mechanism that results in a detailed operational process for building both software and an argument demonstrating its fitness for use in given operating contexts. In this paper, we intro...

W model a situation in which two retailers consider launching an “Advance Booking Discount” (ABD) program. In this program, customers are enticed to precommit their orders at a discount price prior to the regular selling season. However, these precommitted orders are filled during the selling season. While the ABD program enables the retailers to lock in a portion of the customer demand and use...

This study deals with the Companion (ṣaḥābi) ‘Abd Allah bin ‘Umar al-Khattāb, may God be pleased them. is an attempt to clarify his positions on political events he lived through and invasions wars in which participated. The researcher’s choice of this topic came due lack historical studies Companions (al-ṣaḥābah) general stages strife that nation was exposed at beginning Islam, including Ibn ‘...

Ubaid-Allah Sindhi is among those very few political thinkers and activists of the twentieth-century India who were initially associated with the traditional theological seminaries but their political vision was marked by liberalism and openmindedness. He established a non-communal political party— Mahabharat Sarvrajia Party in 1924 in order to translate his political ideals into practice. The ...

The Drosophila larval cardiac tube is composed of 104 cardiomyocytes that exhibit genetic and functional diversity. The tube is divided into the aorta and the heart proper that encompass the anterior and posterior parts of the tube, respectively. Differentiation into aorta and heart cardiomyocytes takes place during embryogenesis. We have observed living embryos to correlate morphological chang...

Many important processes in eukaryotic cells involve changes in the quantity, location and the organization of actin filaments [1] [2] [3]. We have been able to visualize these changes in live cells using a fusion protein (GFP-ABD) comprising the green fluorescent protein (GFP) of Aequorea victoria and the 25 kDa highly conserved actin-binding domain (ABD) from the amino terminus of the actin c...

Islamic art is unique because its form and function permeate both distance and time. Since the birth of Islam, Muslim artists around the world have created pieces of art that share an uncanny resemblance to pieces created by other Muslim artists through common themes, appearances, and applications. These similarities include calligraphic elements, exaggerated depictions of plants and animals, a...

The Qur’an does not mention a lot of alcohol, but pedagogically it explains its gradual ban in a convenient way by pointing out that alcohol is not used in a “good” benefit. Say, “My Lord has only forbidden immoralities what is apparent of them and what is concealed and sin, and oppression without right, and that you associate with Allah that for which He has not sent down authority, and that y...

BACKGROUND In Drosophila, the gonads are composed of two cell populations: the germ line, derived from the pole cells, and a somatic component, derived from the mesoderm of abdominal segments 5-8. Formation of the gonad requires the function of a specific homeotic gene, abdominal-A (abd-A). Other genes of the bithorax complex, Ultrabithorax (Ubx) or Abdominal-B (Abd-B), cannot substitute for th...