OBJECTIVE Therapy-related myeloid neoplasms (t-MN) account for approximately 10% to 20% of all cases of AML (acute myeloid leukemia), MDS (myelodysplastic syndrome) and MDS/MPN (myelodysplastic syndrome/myeloproliferative neoplasms), MDS, and MDS/MPN. In our study, we evaluated peripheral blood smear samples and hemogram values in breast cancer patients who were receiving adjuvant anthracycline...

La chorée-acanthocytose (ChAc) est une affection autosomique récessive très rare causée par des mutations dans le gène VSP13A sur le chromosome 9q21. Elle est caractérisée par des signes neurologiques, des manifestations psychiatriques et une atteinte multisystémique comportant une myopathie, une neuropathie axonale et la présence de globules rouges spiculées ou acanthocytes. Rarement, l’épilep...

A VARIETY OF RED CELLS with one or more spiny projections has been 1-1._ described and some of these spiculed cells have been associated with specific congenital or acquired hemolytic anemias. Of these, only sickle cells are well defined morphologically, etiologically, and pathogenically. Tear drop cells are sharply defined morphologically and have been associated most prominently with myelofib...

Blood cell abnormalities may occur among COVID-19 patients and could be detrimental during the disease’s progression. This study assessed complete blood count (CBC) parameters determined abnormal changes in peripheral of receiving care at Komfo Anokye Teaching Hospital (KATH), Ghana. hospital-based descriptive cross-sectional conducted KATH, Kumasi, Ghana, recruited seventy-three (73) RT-PCR-co...

N'-Nitrosodiethylamine (NDEA) is an effective hepatotoxicant, carcinogen and mutagen. NDEA-induced hepatic necrosis, through metabolic activation by CYP2E1, is an extensively used experimental model. In the present study, we analysed the dose- and time-dependent effect of NDEA on hepatic damage, RBC rheology and proteomic profile in male Wistar rats. The rats, 5-6 weeks old, were divided into f...

Background: Morphological examinations of urinary erythrocytes can be of diagnostic value in initial evaluation of hematuria. Dysmorphic urinary red blood cells are known to indicate a glomerular origin of bleeding. We examined the clinical usefulness of this test in a population complained of hematuria by use of three different methods: light microscopy, phase contrast microscopy, and Wright s...

Abstract Background and Aims Postinfectious glomerulonephritis (PIGN) is a disease presented as nephritic syndrome with hypocomplementemia usually secondary to skin or throat infection by beta hemolytic Streptococcus histopathological findings of endocapillary proliferation, C3 deposits along the capillary wall mesangium, subepithelial immune complex IF positive for IgG. There are other unusual...

Ras makes a pit stop R as proteins are restless, continually fl itting from the cell membrane to the Golgi apparatus and back again. Misaki et al. reveal that the proteins enter recycling endosomes during the journey to the plasma membrane. One mystery is why Ras proteins—which spur cell growth, differentiation, and survival—move so often. The cluttered cell interior has also made it diffi cult...

Chorea-acanthocytosis (ChAc) is a fatal neurological disorder characterized by red blood cell acanthocytes and striatal neurodegeneration. Recently, severe cell membrane disturbances based on depolymerized cortical actin and an elevated Lyn kinase activity in erythrocytes from ChAc patients were identified. How this contributes to the mechanism of neurodegeneration is still unknown. To gain ins...

Background: Morphological examinations of urinary erythrocytes can be of diagnostic value in initial evaluation of hematuria. Dysmorphic urinary red blood cells are known to indicate a glomerular origin of bleeding. We examined the clinical usefulness of this test in a population complained of hematuria by use of three different methods: light microscopy, phase contrast microscopy, and Wright s...