Inhibition of growth signaling pathways protects against aging and age-related diseases in parallel with reduced oxidative stress. The relationships between growth signaling, oxidative stress and aging remain unclear. Here we report that in Saccharomyces cerevisiae, alterations in growth signaling pathways impact levels of superoxide anions that promote chronological aging and inhibit growth ar...

aging coefficient (ac) or aged-child ratio or age composition; takes into account the numbers and areas at both ends of the age distribution simultaneously. ac is the total number of individuals aged 65 years and more, divided by the total number of individuals aged 14 years, multiplied by 100. herein, age composition in iranian popu1ations, according to different provinces, place of residence ...

For multicellular organisms, different tissues coordinate to integrate physiological functions, although this systematically and gradually declines in the aging process. Therefore, an association exists between tissue coordination and aging, and investigating the evolution of tissue coordination with age is of interest. In the past decade, both common and heterogeneous aging processes among tis...

Structural characteristics influence assessment of fatigue cracking behavior. In the asphalt pavements, structure and practical conditions must be considered. This study analyzes changes in elastic modulus pavement different mixtures amid aging moisture damage through tests. A model to predict tensile strain at bottom layer is developed a structural analysis based on material properties. The re...

An enhanced or abnormal inflammatory response to the lungs to inhaled particles and gases, usually from cigarette smoke, is considered to be a general pathogenic mechanism in COPD (chronic obstructive pulmonary disease). Activation of leucocytes and the development of oxidant-antioxidant and protease-anti-protease imbalances are thought to be important aspects of this enhanced inflammatory resp...

In spite of great efforts, the mechanisms for postovulatory oocyte aging are not fully understood. Although our previous work showed that the FasL/Fas signaling facilitated oocyte aging, the intra-oocyte signaling pathways are unknown. Furthermore, the mechanisms by which oxidative stress facilitates oocyte aging and the causal relationship between Ca2+ rises and caspase-3 activation and betwee...

The nematode worm Caenorhabditis elegans provides a powerful system for elucidating how genetic, metabolic, nutritional, and environmental factors influence aging. The mechanistic target of rapamycin (mTOR) kinase is important in growth, disease, and aging and is present in the mTORC1 and mTORC2 complexes. In diverse eukaryotes, lifespan can be increased by inhibition of mTORC1, which transduce...

Lightweight, age-hardenable aluminum alloys are attracting increasing attention as a means to reduce vehicle mass and improve fuel economy. To accelerate the adoption of these alloys, knowledge of the complex precipitation processes that underlie their primary strengthening mechanism is essential. Here we employ a combination of atom-probe tomography (APT), differential scanning calorimetry (DS...

Taurine (2-aminoethanesulfonic acid) is found in milimolar concentrations in mammalian tissues. One of its main functions is osmoregulation; however, it also exhibits cytoprotective activity by diminishing injury caused by stress and disease. Taurine depletion is associated with several defects, many of which are found in the aging animal, suggesting that taurine might exert anti-aging actions....

OBJECTIVE In the present study, we investigated the antioxidant and anti-aging effects of Silybum marianum protein hydrolysate (SMPH) in D-galactose-treated mice. METHODS D-galactose (500 mg/kg body weight) was intraperitoneally injected daily for 7 weeks to accelerate aging, and SMPH (400, 800, 1,200 mg/kg body weight, respectively) was simultaneously administered orally. The antioxidant and...