This study identified gene expression profiles that provided evidence for genomic mechanisms underlying the pathophysiology of aging lung. Aging lungs from C57BL/6 (B6) and DBA/2 (D2) mouse strains differ in physiology and morphometry. Lungs were harvested from B6 mice at 2, 18, and 26 mo and from D2 mice at 2 and 18 mo of age. Purified RNA was subjected to oligonucleotide microarray analyses, ...

The viscoelastic properties of cylinders (diameter 5 mm, height 2.2 ± 0.2 mm) of Nagor silicone elastomer of medium hardness, were investigated before and after the specimens had undergone accelerated aging in saline solution at 70°C for 38, 76 and 114 days (to simulate aging at 37°C, for 1, 2 and 3 years, respectively). All sets of specimens were immersed in physiological saline solution at 37...

An enhanced or abnormal inflammatory response to the lungs to inhaled particles and gases, usually from cigarette smoke, is considered to be a general pathogenic mechanism in COPD (chronic obstructive pulmonary disease). Activation of leucocytes and the development of oxidant-antioxidant and protease-anti-protease imbalances are thought to be important aspects of this enhanced inflammatory resp...

Abstract: Mineral oil is widely used as liquid insulation in high voltage equipment. Due to environmental considerations, recently natural esters have been considered as naturally friendly liquid insulation candidates for high voltage transformers. In this experiment, transformer insulation paper was subjected to get accelerated aging test with copper strip in natural ester in a hermeneutical h...

The effects of accelerated aging on a pigmented elastomer were evaluated by using a weathering chamber. Silastic 44210, a maxillofacial material with proven color and physical property stability, was chosen for pigmentation with 11 maxillofacial pigments. The values of ultimate tensile strength, maximum percent elongation, shear strength, Shore A hardness, and permanent deformation were determi...