Multiple molecular dynamics simulations and a systematic analysis of sequence and structure of mammalian cytochrome P450 monooxygenases were performed to investigate the structural basis of their specificity and selectivity. While the substrate binding cavity is mobile, the protein core and the access funnel to the heme are rigid. High mobility of the substrate binding pocket is consistent with...

Different quantum states of atoms in optical lattices can be nondestructively monitored by off-resonant collective light scattering into a cavity. Angle resolved measurements of photon number and variance give information about atom-number fluctuations and pair correlations without single-site access. Observation at angles of diffraction minima provides information on quantum fluctuations insen...

Introduction Abnormal uterine bleeding is a major gynecological problem, accounting for 33% of outpatient referrals, including 69% of referrals in peri-menopausal, and postmenopausal age group.[1,2] Evaluation of abnormal uterine bleeding in women ≥40 years or menopausal women is of critical importance to confirm the benign nature of the problem, and to exclude endometrial carcinoma, so that me...

We consider light scattering from ultracold quantum gas in optical lattices into a cavity. The measurement of photons leaking out of the cavity enables a quantum nondemolition access to various atomic variables. The time resolved light detection projects the motional state to various atom-number squeezed and macroscopic superposition states that strongly depend on the geometry. Modifications of...

Prion infection and pathogenesis are dependent on the agent crossing an epithelial barrier to gain access to the recipient nervous system. Several routes of infection have been identified, but the mechanism(s) and timing of in vivo prion transport across an epithelium have not been determined. The hamster model of nasal cavity infection was used to determine the temporal and spatial parameters ...

most mandibular second molars have one and two canals in distal and mesial roots, respectively. this report represents four cases of mandibular second molars with a single mesial and two distal root canals with two different canal configurations. after access cavity preparation, two teeth had one distal and two mesial orifices, whereas in the two other teeth one mesial and two distal orifices w...

We present a novel system where an optical cavity is integrated with a microfabricated planar-electrode ion trap. The trap electrodes produce a tunable periodic potential allowing the trapping of up to 50 separate ion chains aligned with the cavity and spaced by 160μm in a one-dimensional array along the cavity axis. Each chain can contain up to 20 individually addressable Yb ions coupled to th...