Clathrin adaptor protein complex-1 (AP-1) and its accessory proteins play a role in the sorting of integral membrane proteins at the trans-Golgi network and endosomes. Their physiological functions in complex organisms, however, are not fully understood. In this study, we found that CG8538p, an uncharacterized Drosophila protein, shares significant structural and functional characteristics with...

AP-2 is the core-organizing element in clathrin-mediated endocytosis. During the formation of clathrin-coated vesicles, clathrin and endocytic accessory proteins interact with AP-2 in a temporally and spatially controlled manner, yet it remains elusive as to how these interactions are regulated. Here, we demonstrate that the endocytic protein NECAP 1, which binds to the α-ear of AP-2 through a ...

BACKGROUND High rates of success using radiofrequency ablation energy have rapidly transformed catheter ablation from an investigational procedure to the nonpharmacological therapy of choice for symptomatic Wolff-Parkinson-White syndrome. Prior studies of radiofrequency accessory pathway ablation were based on a ventricular approach. Risks associated with prolonged arterial catheter manipulatio...

A 'concealed' accessory pathway was suspected in 12 patients because of eccentric left atrial activation during tachycardia. Retrograde conduction during ventricular pacing may occur over the atrioventricular node, the accessory pathway, or both. There were 4 patterns of ventriculoatrial conduction in response to ventricular extrastimuli (V2) at various coupling intervals: (1) exclusive accesso...

Background Epidemiological data indicate that 0.1% to 0.3% of the general population have ECG findings suggesting that during sinus rhythm, in addition to AV conduction over the AV node His pathway, there is also AV conduction over an accessory AV pathway (AP).4 This means that each year 4 new cases are found in a population of 100 000. It is also known that there is a 4-fold increase of this f...

We have previously reported the use of an epicardial approach for ablation of left ventricular free wall accessory atrioventricular pathways. The technique involves mobilization of the atrioventricular fat pad and exposure and cryoablation of the atrioventricular junction at the site of the accessory pathway on the normothermic beating heart. Here we describe our further experience with left ve...

Transcatheter radiofrequency ablation of supraventricular tachycardia was first introduced in 1987. The procedure is now well-accepted as primary treatment for supraventricular tachycardia in paediatric patients. In this report we describe our experience of radiofrequency ablation of accessory pathway mediated supraventricular tachycardia in the past 10 years. From 1994 to 2005, 121 procedures ...

Abstract Funding Acknowledgements Type of funding sources: None. Background and purpose High density (HD) mapping is associated with a reduction in fluoroscopy time compared to conventional accessory pathway (AP) ablation. The Open Window (OW) technique (CARTO 3, Biosense Webster) new tool that automatically uses electrophysiology criteria for AP location, as shorter local EGM AV interval (exte...

A 47-year-old man was referred to our hospital due to recurrent episodes of narrow QRS complex tachycardia. Baseline electrocardiogram showed ventricular pre-excitation in favour of left-sided accessory pathway (AP), so we decided to perform radiofrequency (RF) mapping and ablation of AP. During the ventricular pacing and orthodromic atrioventricular reciprocating tachycardia, the earliest atri...

In 1930, Dr Louis Wolff, Sir John Parkinson, and Paul Dudley White described a case series of 11 patients with a syndrome that now bears their name.1 The first patient with a short PR interval, ventricular preexcitation, and supraventricular tachycardia was described by Cohn and Fraser in 1913.1 Wood et al postulated the accessory pathway (AP) as its anatomic substrate in 1942, and a large popu...