Acebutolol ('Sectral'), a cardioselective beta-blocking drug, was administered intravenously in a dose of 25 mg to 10 patients with congestive cardiomyopathy. All of them were in a stable condition on antifailure regimens. The drug resulted in a statistically significant decline in left ventricular contractility as judged by peak left ventricular dP/dT and the contractility index. The mean aort...

Increasing the dose of a thiazide diuretic used alone in patients with essential hypertension has little further effect on blood pressure but increases the deleterious metabolic consequences of the diuretic. The effect of a beta-blocker on this flat dose response is not known. In two randomised crossover studies the effect of 12.5 mg, 25 mg, and 50 mg hydrochlorothiazide combined with 400 mg ac...

During a double-blind crossover study of hydrochlorothiazide (HCT) and acebutolol (ACB), 11 patients 45 to 69 years old with essential hypertension underwent studies of forearm blood flow (FBF), arterial resistance (FAR), and venous compliance (FVC) using mercury-in-Silastic plethysmography. Placebo periods of 12 weeks were followed by a variable period of incremental doses of either active dru...

Apresenta-se um sistema mecanizado para a determinação de β–bloqueadores em preparações farmacêuticas. Através da utilização da técnica de Análise de Injeção Sequencial (SIA) foi obtida uma metodologia simples, econômica e versátil, adaptável a todo o tipo de controlo farmacêutico envolvendo estas substâncias. As amostras não necessitam de pré-tratamento devendo apenas ser dissolvidas em ácido ...