Polarization of the actin cytoskeleton is vital for collective migration cells in vivo. During invasive border cell Drosophila, polarization directly controlled by Hippo signaling complex, which resides at contacts between cluster. Here, we identify, a genetic screen deubiquitinating enzymes involved migration, an essential role nonstop/USP22 expression pathway components expanded and merlin. L...

The effects of semi-chronic stress on neuronal morphology and choline acetyltransferase were studied by injecting rats with dexamethasone. It was found that in the dexamethasone-treated rats the choline acetyltransferase activity had increased in the area where the fibers from the perforant pathway synapse with the granular cell layer of the dentate gyrus and also where the mossy fibers of the ...

Acetyl-CoA:N-hydroxyarylamine O-acetyltransferase is an enzyme involved in the metabolic activation of N-hydroxyarylamines derived from mutagenic and carcinogenic aromatic amines and nitroarenes. The O-acetyltransferase gene of Salmonella typhimurium has been cloned, and new Ames tester substrains highly sensitive to mutagenic aromatic amines and nitroarenes have been established in our laborat...

The lag period in the induction of rat pineal N-acetyltransferase (arylamine acetyltransferase or acetyl-CoA:arylamine N-acetyltransferase EC 2.3.1.5) by catecholamines via the beta-adrenergic receptor varies with the length of exposure of the rat to light or darkness. If rats have been exposed to light and reduced sympathetic nerve activity for more than 12 hr, this lag period is 1-2 hr long. ...

We review the relation between the matrix model and Liouville approaches to two-dimensional gravity as elaborated by Moore, Seiberg and Staudacher. Then, based on the supersymmetric Liouville formulation and the discrete eigenvalue model proposed by Alvarez-Gaumé, Itoyama, Mañes and Zadra, we extend the previous relation to the supersymmetric case. The minisuperspace approximation for the super...

Cerebral accumulation of amyloid A protein (AA) is characteristic of Alzheimer disease (AD). AA can be detected in cerebrospinal fluid and in plasma. Although plasma AA has been proposed as a marker of risk of AD, it is unknown how plasma levels relate to neuropathologic levels. We compared plasma levels of AA40 and AA42 obtained during life with biochemical and pathologic levels in frontal and...

The effects of semi-chronic stress on neuronal morphology and choline acetyltransferase were studied by injecting rats with dexamethasone. It was found that in the dexamethasone-treated rats the choline acetyltransferase activity had increased in the area where the fibers from the perforant pathway synapse with the granular cell layer of the dentate gyrus and also where the mossy fibers of the ...

Transcription initiation is a major regulatory step in eukaryotic gene expression. It involves the assembly of general transcription factors and RNA polymerase II into functional pre-initiation complex at core promoters. The degree chromatin compaction controls accessibility machinery to template DNA. Co-activators have critical roles this process by actively regulating accessibility. Many tran...