Based on their versatility with respect to amino acid type and sequence, polypeptides have become attractive for a number of biological applications such as drug delivery, biomineralization, and drugs. N-carboxy anhydride (NCA) polymerization is a convenient way to rapidly prepare high-molecular weight polypeptides with good control over molecular weight and polydispersity. However, the kinetic...

Salicylic acid (SA) based biodegradable polyanhydrides (PAHs) are of great interest for drug delivery in a variety of diseases and disorders owing to the multi-utility of SA. There is a need for the design of SA-based PAHs for tunable drug release, optimized for the treatment of different diseases. In this study, we devised a simple strategy for tuning the release properties and erosion kinetic...

A recent report has indicated that the oxidizing agent Oxone does not possess the ability to cleave the 2,3-carbon-carbon bond of indole. Work in our laboratory shows that this is not the case. Indole and a variety of aryl ring substituted derivatives readily react to form synthetically important isatoic anhydrides.

An improvement of the efficiency of organic chemical synthesis was attempted by the imitation of natural reactions. Phosphorylated amino acid derivatives and the rupture of thus obtained »high energy phosphates« was used for aminoacylations of 6-11minopenicillanic acid (6-APA). Namely, the energy-rich mixed anhydrides, formed from adenosine triphosphate (ATP) and amino acids were shown to be th...

The difructose anhydrides include four welldefined crystalline sugars. Diheterolevulosan was first prepared by Pictet and Chavan [1]l by the action of concentrated hydrochloric acid on fructose at 0° C. This sugar is a difructopyranose in which carbon atoms 1 and 2 of each fructose residue are joined to form a dioxane ring. The other members [2,3] of this group arc designated difructose anhydri...

The global reaction between acetic anhydride and a fatty acid yields, at equilibrium, an asymmetric acetic-aliphatic anhydride in a medium containing finally: acetic-fatty anhydride, acetic anhydride, fatty acid, acetic acid and fatty anhydride. No solvent or catalyst was used to evaluate the impact of the actual reactivity of the anhydrides. The competition between the formation of acetyl and ...