Acrylamide has been used to investigate the biochemical and morphological changes in developing rat cerebrum following exposure in pregnant rats. Non-anesthetized pregnant rats were given 10 mg/kg/day of acrylamide by gastric intubation. The pups were divided into 3 groups: Group A (control group); Group B ( prenatal exposure); and Group C (perinatal exposure). Acrylamide-induced biochemical an...

Two factors have stimulated the present intense investigation of acrylamide neurotoxicity. These are the health hazard accompanying the vast and increasing industrial production of acrylamide, and the promise of illuminating the mechanism of dying-back disease in the human nervous system by employing acrylamide as an experimental tool. The present paper discusses the industrial uses of acrylami...

It is unclear whether the association between dietary acrylamide intake and endometrial cancer risk as observed in some epidemiological studies reflects a causal relationship. We aimed at clarifying the causality by analyzing acrylamide-gene interactions for endometrial cancer risk. The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline,...

Changes in the sugar and amino acid contents of potato tubers during short-term storage and the effect on the acrylamide level in chips after frying were investigated. The acrylamide content in chips began to increase after 3 days of storage at 2 degrees C in response to the increase of glucose and fructose contents in the tubers. There was strong correlation between the reducing sugar content ...

We have developed a liquid chromatography/mass spectrometry (LC-MS/MS) assay to determine acrylamide in various body fluids. The assay also allows the reliable quantitation of acrylamide in food. In a total of 11 healthy male and female subjects, we were able to show that acrylamide from food given to humans is in fact absorbed from the gut. The half-lives determined in two male subjects were 2...

Acrylamide, a chemical that is probably carcinogenic in humans and has neurological and reproductive effects, forms from free asparagine and reducing sugars during high-temperature cooking and processing of common foods. Potato and cereal products are major contributors to dietary exposure to acrylamide and while the food industry reacted rapidly to the discovery of acrylamide in some of the mo...

European Snacks Association (ESA) data on acrylamide in potato crisps from 2002 to 2019 (99704 observations) were analysed. Acrylamide levels have plateaued since 2011, although the lowest mean so ...

Acrylamide concentrations in prune products--baby strained prunes (range = 75-265 µg kg(-1)), baby apple/prune juice (33-61 µg kg(-1)), prune juice (186-916 µg kg(-1)) and prunes (58-332 µg kg(-1))--on the Canadian market were determined. The formation of acrylamide in a simulated plum juice was also investigated under 'drying conditions' in an open vessel at temperatures <100°C for 24 h and un...

Acrylamide is a probable human carcinogen that was detected in several heat-treated foods, such as French fries and crisps, in 2002. Prospective studies are needed on acrylamide and human cancer risk. We prospectively investigated the association between acrylamide and gastrointestinal cancer risk. In 1986, 120,852 men and women (aged 55-69 y) were included in the Netherlands Cohort Study on di...