c-Jun is an oncoprotein that activates transcription of many genes involved in cell growth and proliferation. We studied the mechanism of transcriptional activation by human c-Jun in a human RNA polymerase II transcription system composed of highly purified recombinant and native transcription factors. Transcriptional activation by c-Jun depends on the TATA-binding protein (TBP)-associated fact...

OBJECTIVE To determine whether increased serum and/or tracheal aspirate fluid (TAF) levels of IL-6 at birth are associated with fetal inflammation in ventilated extremely low gestational age newborns (ELGAN). METHOD A total of 36 ELGAN who required mechanical ventilation were enrolled in this study. The patients were classified into two groups: 19 infants who displayed histological evidence o...

TAF(II)250, the largest subunit of the general transcription factor TFIID, is expressed from the human X chromosome, at least in somatic cells. In male meiosis, however, the sex chromosomes are transcriptionally silenced, while the autosomes remain active. How then are protein-encoding genes transcribed during human male meiosis? Here we present a novel autosomal human gene, TAF1L, which is hom...

Coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide (E/C/F/TAF) has high efficacy and improved renal and bone safety in multiple phase 3 trials; TAF single agent is being studied in 2 phase 3 trials in patients with chronic hepatitis B. We report the results of an open-label, noncomparative switch study evaluating the efficacy and safety of E/C/F/TAF in HIV/hepatitis...

The optimum road spacing has been studied by many researches. It is an important step of forest road network planning. The goals of this study are determining the optimum road spacing in Kheiroudkenar forest of Nowshahr in Northern Iran and study of effect of kind of skidder on skidding cost and road spacing. Continues time study method was used to determine the production rate of TAF and Timbe...

Initiation of transcription of protein-encoding genes by RNA polymerase II was thought to require the transcription factor II D (TF(II)D), a complex comprising the TATA binding protein (TBP) and TBP-associated factors. However, another multiprotein complex isolated more recently and called TFTC (TBP-free TAF(II )containing complex), was shown to mediate initiation of RNA polymerase II (Pol II) ...

BACKGROUND Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir that shows enhanced antiretroviral effect and reduced plasma tenofovir exposures at approximately one-tenth the clinically approved dose of tenofovir disoproxil fumarate (TDF). Tenofovir released from TDF undergoes active renal secretion via organic anion transporters (OAT1 and OAT3), leading to higher exposure of renal prox...

Background. For general aviation (GA) pilots, operations in instrument meteorological conditions (IMC) carry an elevated risk of a fatal accident. As to whether flight can be safely undertaken, aerodrome-specific forecasts (TAF, LAMP) provide guidance. Although LAMP are more common for GA-frequented aerodromes, nevertheless, the FAA recommends that such aerodromes (and which TAF is not issued) ...

Objective: The aim of the current study was to investigate the role of fusion beliefs and metacognitions in obsessive–compulsive symptoms in the general population. Methods: A sample of 200 students of Kharazmi University was selected from various faculties and completed the following questionnaires: Metacognitions Questionnaire-30 (MCQ-30), Thought-Fusion Instrument (TFI) and Maudsley Obses...

Normal, viral transformed and tumor-derived cells grown in tissue culture and representing different species were tested for their ability to produce an extracellular tumor angiogenesis factor (TAF). TAF was assayed by measuring the host-mediated vascular response of the chorioallantoic membrane to TAF preparations. All of the viral transformed and tumor-derived cells tested, including SVT2, SV...