Intelligence and Knowledge play more and more important roles in building complex intelligent systems, for instance, intrusion detection systems, and operational analysis systems. Knowledge processing in complex intelligent systems faces new challenges from the increased number of applications and environment, such as the requirements of representing domain and human knowledge in intelligent sy...

PURPOSE To retrospectively determine the sensitivity of and number of false-positive marks made by a commercially available computer-aided detection (CAD) system for identifying lung cancers previously missed on chest radiographs by radiologists, with histopathologic results as the reference standard. MATERIALS AND METHODS Institutional review board approval was obtained for this HIPAA-compli...

The DataNet Federation Consortium uses a policy-based data management system to apply and enforce preservation requirements. This paper describes the Preservation Policy Toolkit developed by the consortium. In particular, the paper describes the infrastructure needed for preservation, presents examples of computer actionable forms of policies, and provides a generic template for designing actio...

The amount of genomic information about leukemia cells currently far exceeds our overall understanding of the precise genetic events that ultimately drive disease development and progression. Effective implementation of personalized medicine will require tools to distinguish actionable genetic alterations within the complex genetic landscape of leukemia. In this study, we performed kinase inhib...

System administrators make security decisions based on data provided by a variety of tools. Yet too often these tools do not structure the presentation of that data to support the communication and decision making needs of a variety of stakeholders within an organization. For example, consider the task of fixing system vulnerabilities based on network scans. Network vulnerability tools produce ...

Despite the increased use of molecular diagnostics, the extent to which patients who have these tests harbor potentially actionable aberrations is unclear. We retrospectively reviewed 439 patients with diverse cancers, for whom next-generation sequencing (mostly 236-gene panel) had been performed. Data pertaining to the molecular alterations identified, as well as associated treatment suggestio...