Mitogen-activated protein kinase (MAPK) cascades are involved in host defense against pathogens and often activated by upstream plasma membrane leucine-rich repeat receptor-like kinases (LRR-RLKs). ERECTA (ER) is an LRR-RLK that regulates plant developmental processes through activating MAPK cascades. Tomato leaf curl Yunnan virus (TLCYnV) C4 interacts with BKI1, stabilizes it at the impairs ER...

ABSTRACT Humans sense taste and smell of various chemical substances through approximately 430 chemosensory receptors. The overall picture ligand–chemosensory receptor interactions has been partially clarified because numerous interactions. This study presents a new method that enables rapid simple screening It would be useful for identifying receptors activated by odor substances.

PURPOSE To assess the effects of Aleglitazar on hyperglycaemia-induced apoptosis. METHODS We incubated human cardiomyocytes, cardiomyocytes from cardiac-specific peroxisome proliferator-activated receptor-γ knockout or wild-type mice in normoglycaemic or hyperglycaemic conditions (glucose 25 mM). Cells were treated with different concentrations of Aleglitazar for 48 h. We measured viability, ...

Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [112]) are activated endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for antagonist-bound [155, 316, 224, 62], agonist-bound [379, 205, 206] and G protein-bound A2A [49] have been described. The of an A1 receptor [130] adenosine-bound receptor-Gi complex [87] resolve...

BACKGROUND & AIMS Protease-activated receptor 2 can be stimulated by interstitially released trypsin during acute inflammation of the pancreas. In this study, we investigated the roles of pancreatic and circulatory protease-activated receptor 2 in the pathogenesis of acute pancreatitis by using in vitro and in vivo model systems. METHODS Physiological and pathologic effects of protease-activa...

Background: The MET receptor is a critical member of cancer-associated RTKs and plays an important role in different biological activities, including differentiation, migration, and cell proliferation. Methods: In this study, novel MET inhibitors were introduced and applied on esophageal squamous carcinoma cell line KYSE-30, and the level of proliferation and migration, as well as the activated...

This study aims to explore the material basis and mechanism of Baoyuan decoction in treatment chronic heart failure by network pharmacology molecular docking technology. There are 144 effective active ingredients 253 targets decoction. The key mainly include flavonoids such as quercetin, naringenin glazin. 240 intersecting between Baoyuantang failure, its core jun proto-oncogene, signal transdu...

Adenosine is a cellular metabolite with diverse derivatives that possesses wide range of physiological roles. We investigated the molecular mechanisms adenosine and cordycepin for their promoting effects in wound-healing process. The mitochondrial energy metabolism cell proliferation markers, cAMP responsive element binding protein 1 (CREB1) Ki67, were enhanced by cultured dermal fibroblasts. s...