Introduction Two major immuno-inflammatory phases are well documented during sepsis: an early active inflammatory phase regulated followed by a deactivated inflammatory phase leading to immunosuppression. Innate immunity, such as monocyte HLA-DR expression (mHLA-DR), has been shown constantly and rapidly decreased. Adaptive immunity modifications have been reported, this appeared less documente...

BACKGROUND & AIMS Hepatitis C virus antiviral treatment is effective for individual patients but few active injecting drug users are treated. We considered the utility of antiviral treatment for primary prevention of hepatitis C. METHODS A hepatitis C transmission model among injecting drug users was developed, incorporating treatment (62.5% average sustained viral response) with no retreatme...

Specific immunologic resistance mechanisms to cytomegalovirus (CMV) have not been extensively studied in either normal subjects or immunosuppressed renal allograft recipients. Such studies are in progress in my laboratory. Humoral immunity to CMV appears to be unimpaired in infected transplant patients. The neutralizing (NT) antibody titers in 24 allograft recipients with active CMV infection w...

1. A substance extracted from group A hemolytic streptococcus is described, which induces active immunity in mice, and in rabbits gives rise to precipitins and to protective antibodies passively transferable to mice. 2. The active immunity in mice is principally type-specific, but some degree of non-type-specific immunity is also developed. The passively transferable protective antibodies are t...

A successful cow/calf operation requires that a large percentage of cows wean a live calf every year. A live calf at weaning time requires survival of the offspring from birth to weaning. USDA beef researchers and rancher surveys report that diseases, including scours and pneumonia, were the second leading cause of baby calf deaths. Difficulty at birth was the single largest source of death los...