A 13-year-old boy with a small ventricular septal defect was admitted with clinical manifestations of acute endocarditis. Coagulase-positive staphylococci were isolated from the blood. Definitive diagnosis was made by detecting bacterial vegetations in the right ventricle on the echocardiogram. Repeated embolization of these vegetations to the pulmonary circulation led to the death of the patient.

Up to 1945 reports of the treatment of bacterial endocarditis with penicillin were disappointing. Early in that year, however, more encouraging results were obtained with larger doses, and it became urgently necessary to determine the optimum dosage. With this end in view a committee was set up by the Penicillin Clinical Trials Committee with Professor R. V. Christie as secretary and representa...

Acute lymphoblastic leukemia (ALL) is a systemic disease that is presented with different symptoms and signs. Cardiac manifestation is rare in ALL, but it is very important and needs appropriate management. It usually presents as leukemic myocardial infiltration and in the presence of cardiac mass comprehensive evaluation for other etiologies is mandatory. We reported on a 6-year-old boy in rem...

We present a case of right-sided infective endocarditis due to methicillin-resistant Staphylococcus aureus that occurred in an injectable drug user. Traditionally, cities such as Detroit and San Francisco have been associated with certain bacterial infections. Upon further review, these relationships appear more tenuous and argue that identification to the level of "strain" will be required to ...

Bacterial endocarditis is a severe infectious disease. of which treatment is traditionally carried out in hospitalized patients through intravenous medication. The possibility of at-home or ambulatory treatment. for stringently selected cases. is attractive from the social as well as from the economic point of view. We report 6 patients with a diagnosis of bacterial endocarditis caused by Strep...

In an attempt to gain information about the "incubation period" of subacute bacterial endocarditis, the literature was searched for case reports stating a specific interval between an event likely to cause bacteremia and the onset of symptoms. In 76 cases of streptococcal endocarditis for which this information was given, the median "incubation period" was one week. Symptoms began within two we...

We report a case of bacterial endocarditis due to Erysipelothrix rhusiopathiae in a homeless man with no animal exposure. His course was complicated by an allergic reaction to ampicillin, urinary bladder infection, respiratory failure, and acute kidney injury. He recovered completely after aortic valve replacement and a 6-week course of intravenous ceftriaxone.

Haemophilus aphrophilus was isolated from the blood of a 31-year-old man with subacute bacterial endocarditis. Subsequently the patient died with acute tubular necrosis of the kidney, probably secondary to cardiac failure. The characteristics of the species are described and pathogenicity to mice is reported for the first time.

Methicillin was introduced in 1959 to treat penicillin-resistant S. aureus infection, however Methicillin-resistant S. aureus (MRSA) was reported 2 years later (1). The most common organism identified in acute infective endocarditis (AIE) is still S. aureus associated with increased hospital mortality, morbidity and hospitalization. In Germany the proportion of MRSA among S. aureus microbiologi...