OBJECTIVE Our aim was to review the emergent neuroimaging findings of alcohol-related CNS nontraumatic disorders. Alcohol (ethanol) promotes inflammatory processes, increases DNA damage, and creates oxidative stress. In addition, the accompanying thiamine deficiency may lead to Wernicke encephalopathy. Associated changes in serum osmolarity may lead to acute demyelination. CONCLUSION Alcohol-...

Neuromyelitis Optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system (CNS) where aquaporin-4 water channels are antigenic target disease. The involves regions CNS channel widely expressed including spinal cord, optic nerve, dorsal medulla, brainstem, and thalamus/hypothalamus. Management NMOSD includes acute as well long term treatment. Acute symptoms t...

The impact of central nervous system (CNS) disorders on the human population is significant, contributing almost €800 billion in annual European healthcare costs. These disorders not only have a disabling social impact but also a crippling economic drain on resources. Developing novel therapeutic strategies for these disorders requires a better understanding of events that underlie mechanisms o...

Worldwide, more than one billion people are affected by CNS disorders. Despite the huge demand for treatments, existing drugs have limited or no efficacy for some neurological diseases, including brain cancer and certain epilepsies. Furthermore, no effective therapies are available at all for some common disorders of the central nervous system (CNS) such as Alzheimer's disease. ATP-binding cass...

abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. we report an 11 years old girl who developed central hypothyroidism and acth deficiency during the chemotherapy for cns relapse of acute lymphoblastic leukemia before receiving radiotherapy. keywords: thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leuk...

Neuroepigenetics is a new emerging field, mainly focusing on epigenetic mechanism study of the central nervous system (CNS). New discoveries show that the CNS-related behaviors, CNS disorders, neural plasticity, neurotoxicity, drug addiction and other neurological disorders are related to the underlying epigenetic mechanisms. Moreover, the development and the function of the human nervous syste...

OBJECTIVE To assess the burden and spectrum of neurological illness in a pediatric intensive care unit and review the associated mortality. METHODS Retrospective review of medical records of children (1 mo-16 years) with acute neurological diagnosis admitted in PICU in Aga Khan University hospital from January 2008 to December 2011 was done. Basic demographic, diagnosis, neuro diagnostic proc...

The classical divide between degenerative and inflammatory disorders of the CNS is vanishing as accumulating evidence shows that inflammatory processes are important in the pathophysiology of primarily degenerative disorders, and neurodegeneration complicates primarily inflammatory diseases of the brain and spinal cord. Here, we review the contribution of degenerative and inflammatory processes...

The complexity and organization of the central nervous system (CNS) is widely modulated by presence blood–brain barrier (BBB) blood–cerebrospinal fluid (BCSFB), which both act as biochemical, dynamic obstacles impeding any type undesirable exogenous exchanges. disruption these barriers usually associated with development neuropathologies can be consequence genetic disorders, local antigenic inv...