Infection of adult C57BL/6 (B6) mice with mouse adenovirus type 1 (MAV-1) results in dose-dependent encephalomyelitis. Utilizing immunodeficient mice, we analyzed the roles of T cells, T-cell subsets, and T-cell-related functions in MAV-1-induced encephalomyelitis. T cells, major histocompatibility complex (MHC) class I, and perforin contributed to acute disease signs at 8 days postinfection (p...

Background: Crimean-congo hemorrhagic fever (CCHF) is an acute tick-borne viral, zoonotic disease with hemorrhagic manifestations and considerable mortality in humans. The purpose of this study was to introduce CCHF as a case report from Babol, north of Iran. It is known as an endemic pathogen in some regions of Iran.Case presentation: We present a case of CCHF suffering from sudden onset of fe...

Acute disseminated encephalomyelitis (ADEM) is a monophasic inflammatory disorder of the central nervous system (CNS). Unlike viral encephalitis, microorganisms do not invade the CNS. Instead, ADEM is a postinfectious disease mediated by auto-reactive cells or molecules. Clinical characteristics of ADEM are consistent with disseminated involvement of the CNS, including encephalopathy and pyrami...

Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating disorder of the central nervous system, and is characterised by multifocal white matter involvement. Diffuse neurological signs along with multifocal lesions in brain and spinal cord characterise the disease. Possibly, a T cell mediated autoimmune response to myelin basic protein, triggered by an infection or vaccination, und...

Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disorder with an acute or subacute onset, typically of a monophasic nature, which affects multifocal areas of the central nervous system. ADEM is commonly associated with an antecedent or concomitant infection that is usually viral. However, in the last few years, several published reports have indicated an association...

High-field MRI is capable of differentiating acute, subacute, and chronic hemorrhagic cortical infarctions. In eight of nine patients, hemorrhage occurred in a vascular watershed zone. Acute hemorrhagic cortical infarction produces mild cortical low intensity on T2-weighted images outlined by subcortical edema (high intensity) and isointensity with normal cortex on T1-weighted images. Subacute ...

Introduction: Acute Disseminated Encephalomyelitis (ADEM) is an immunity-mediated central nervous system demyelinating disorder. Myelin Oligodendrocyte Glycoprotein (MOG) examination provides information about a patient's ADEM development status. A positive MOG antibody can signify first episode or incomplete recovery. This review aims to report case of pediatric patient with acute disseminated...

Introduction. Myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD) are immunemediated inflammatory conditions of the central nervous system (CNS) with a wide clinical phenotypic variability. In order to further understand possible phenotype MOGAD here we report pediatric case acute disseminated encephalomyelitis (ADEM) MOG antibodies. Case outline. A previously healthy four...

BACKGROUND AND PURPOSE Prediction of hemorrhagic transformation in acute ischemic stroke could help determine treatment and prognostication. With increasing numbers of patients with acute ischemic stroke undergoing multimodal CT imaging, we examined whether CT perfusion could predict hemorrhagic transformation in acute ischemic stroke. MATERIALS AND METHODS Patients with acute ischemic stroke...