BACKGROUND AND PURPOSE In acute ischemic stroke, the amount of neuronal damage in hyperintense areas on MR diffusion imaging (DWI) is unclear. We used spectroscopic imaging to measure N-acetyl aspartate (NAA, a marker of normal neurons) and lactate (a marker of ischemia) to compare with diffusion and perfusion values in the diffusion lesion in acute ischemic stroke. METHODS We recruited patie...

Summery. The aim — analysis of preliminary experience treatment COVID-19-associated acute lower limbs ischemia in elderly and senile patients.
 Materials methods. We examined 48 patients (age 60- 84 years). First group 16 with ischemia, second 32 chronic limb without coronavirus infection. .
 Results discussion. group’s had extended blood clotting time (more than 13-15 min). Other ind...

objective(s) opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema. in the present study, we investigated whether spontaneously withdrawal syndrome might affect stroke outcomes. materials and methods addiction was induced by progressive incremental doses of morphine over 7 days. behavioral signs...

This article outlines the therapeutic mechanisms of hyperbaric oxygenation in acute stroke, based on information obtained from peer-reviewed medical literature. Hyperbaric oxygen is an approved treatment modality for ischemia-reperfusion injury in several conditions. It maintains the viability of the marginal tissue, reduces the mitochondrial dysfunction, metabolic penumbra, and blocks inflamma...

T lymphocytes are key contributors to the acute phase of cerebral ischemia reperfusion injury, but the relevant T cell-derived mediators of tissue injury remain unknown. Using a mouse model of transient focal brain ischemia, we report that IL-21 is highly up-regulated in the injured mouse brain after cerebral ischemia. IL-21-deficient mice have smaller infarcts, improved neurological function, ...

Progressive neurological deterioration in patients with recent stroke or transient ischemic attack (TIA) is a distressing and all too common occurrence. Anticoagulation is an important therapeutic consideration for many of these patients. The use of heparin in patients with acute brain ischemia will be reviewed in this paper. Anticoagulation with heparin is often considered in the following cli...

raphy as a guide to conservative therapy. J Neurosurg 1967;27: 353 7. Davis KR, Taveras JM, New PFJ, Schnur JA, Robertson GH. Cerebral infarction diagnosis by computerized tomography: analysis and evaluation of findings. AJR Am J Roentgenol 1975;124: 643 8. Inoue Y, Takemoto K, Miyamoto T, et al. Sequential computed tomography scans in acute cerebral infarct. Radiology 1980;135: 655–662 9. Wein...

Therapy for acute ischemic stroke can be approached in two basic ways: first, by an attempt to restore or improve blood flow in an occluded vascular territory and, second, via therapy directed at the cellular and metabolic targets. As local anoxia and energy failure are the initiating cellular stage in ischemia, the inhalation of oxygen at increased atmospheric pressures might be effective. Tre...

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