The acute phase response is a nonspecific and complex reaction of an organism that occurs shortly after any tissue injury. The origin of this response can be attributable to infectious, traumatic, immunologic, neoplastic, or other causes, in order to restore homeostasis, reduce tissue damage, and to remove the cause of disturbances [1]. The acute phase response is characterized by a number of d...

Hepatocyte and immune system: acute phase reaction as a contribution to early defence mechanisms Cytokines, a variety of hormone-like molecules, include a group of soluble factors-the interferons, interleukins, and hematopoietic growth factors. They build a complex network of interactive signals and are important for the regulation of hematopoesis and many immune reactions. The interaction of t...

Background: Acute-phase proteins (APPs) may be increased due to different stresses during estrus phase in farm animals. Aims: Determining changes of APPs at different phases of non-synchronized estrous cycle group (NSEG), and Ovsynch-synchronized estrous cycle group (SEG) in Holstein cows. Methods: Twelve non-pregnant clinically and paraclinicaly healthy Holstein cows with a body condition scor...

BACKGROUND In patients with cirrhosis, infection is frequent and a leading cause of death. This is secondary to various immunologic abnormalities in both the innate and the adaptive immune system. However, it remains unclear whether cirrhosis affects the inflammatory systemic component of the innate immunity, 'the acute phase response', mostly effectuated by the liver itself. We hypothesized th...

A number of laboratory and clinical studies have shown that interleukin-6 is the principal mediator of the acute phase protein response. In this study the relationship between serum concentrations of interleukin-6 and C-reactive protein in acute pancreatitis are examined and the ability of interleukin-6 to discriminate between severe and mild attacks is assessed. We have studied 24 patients (10...

Inhalation of ambient and workplace particulate air pollution is associated with increased risk of cardiovascular disease. One proposed mechanism for this association is that pulmonary inflammation induces a hepatic acute phase response, which increases risk of cardiovascular disease. Induction of the acute phase response is intimately linked to risk of cardiovascular disease as shown in both e...