A long time ago now (maybe 1988?), Gerald (Gazdar) and I supervised Adam’s DPhil at the University of Sussex. Adam was my age, give or take a year, having come to academia a little late, and was my first doctoral student. Adam’s topic was polysemy, and I’m not really sure that much supervision was actually required, though I recall fun exchanges trying to model the subtleties of word meaning us...

I. Gutman, J. H. Koolen, V. Moulton, M. Parac, T. Soldatović, and D. Vidović Faculty of Science, University of Kragujevac, P. O. Box 60, YU-34000 Kragujevac, Yugoslavia a FSPM-Strukturbildungsprozesse, University of Bielefeld, D-33501 Bielefeld, Germany b Physics and Mathematics Department (FMI), Mid Sweden University, Sundsvall, S-85170, Sweden c Faculty of Physical Chemistry, University of Be...

Jacob Beal1 Ron Weiss2 Douglas Densmore3 Aaron Adler1 Jonathan Babb2 Swapnil Bhatia3 Noah Davidsohn2 Traci Haddock3 Fusun Yaman1 Richard Schantz1 Joseph Loyall1 BBN Technologies 10 Moulton Street Cambridge, MA, USA 02138 MIT 77 Massachusetts Ave Cambridge, MA, USA 02139 Boston University 8 Saint Mary’s St. Boston, MA, USA 02215 {jakebeal,fyaman, aadler, rschantz, jloyall}@bbn.com, {rweiss, ndav...

The metalloprotease ADAM 10 is an important APP alpha-secretase candidate, but in vivo proof of this is lacking. Furthermore, invertebrate models point towards a key role of the ADAM 10 orthologues Kuzbanian and sup-17 in Notch signalling. In the mouse, this function is, however, currently attributed to ADAM 17/TACE, while the role of ADAM 10 remains unknown. We have created ADAM 10-deficient m...

We have identified and cloned a human fetal lung cDNA encoding a new protein of the ADAM-TS family (a disintegrin and metalloproteinase domain, with thrombospondin type-1 modules) that has been called ADAM-TS12. This protein exhibits a domain organization similar to the remaining family members including a propeptide and metalloproteinase-like, disintegrin-like, and cysteine-rich domains. Howev...

An illustrated key is provided for the identification of 65 genera of Thripinae from South East Asia. Wherever possible notes are given on the host-plant associations and geographical distributions, and suggestions made concerning phylogenetic relationships. The combination Taeniothrips euophthalmos Moulton is re-established.

Authors: David Gravette, Pharm.D. Candidate, Harrison School of Pharmacy, Auburn University; Morgan Luger, Pharm.D. Candidate, Harrison School of Pharmacy, Auburn University; Jay Moulton, Pharm.D. Candidate, Harrison School of Pharmacy, Auburn University; Wesley T. Lindsey, Pharm.D., Associate Clinical Professor of Pharmacy Practice, Drug Information and Learning Resource Center, Harrison Schoo...

Colorectal carcinoma is a frequent cause of cancer-related death in men and women throughout the world. MicroRNAs are endogenous small noncoding RNAs that negatively regulate gene expression at the posttranscriptional level. We investigated the role of ADAM-17 (a desintegrin and metalloproteases 17) as a novel multidrug resistance (MDR) mechanism in multidrug-resistant colorectal carcinoma (CRC...