Complex neuroadaptations within key nodes of the brain's "reward circuitry" are thought to underpin long-term vulnerability to relapse. A more comprehensive understanding of the molecular and cellular signaling events that subserve relapse vulnerability may lead to pharmacological treatments that could improve treatment outcomes for psychostimulant-addicted individuals. Recent advances in this ...

Animal models of relapse to drug-seeking have borrowed heavily from associative learning approaches. In studies relapse-like behaviour, animals learn self-administer drugs then receive a period extinction during which they inhibit the operant response. Several triggers can produce recovery responding form basis variety models. These include passage time (spontaneous recovery), drug availability...

The effects of alcohol have been widely studied during the past century, corroborating the idea that this tiny chemical compound acts throughout most of our neurotransmitter systems since it is capable of inducing addictive behaviour. Two of the most serious problems of alcohol addiction are craving and relapse; several studies have demonstrated that relapse is related to the anxious state whic...

Abstract Addiction is characterized by a persistent cycle of drug seeking and taking as well high relapse rate. Neuroimaging technology offers an opportunity to elucidate the brain neurobiology in addiction, with particular attention those circuits implicated reward processing, memory cognitive control etc. Here, we summarized neuroimaging evidence addiction reveal structural functional plastic...

BACKGROUND As we known, Traditional Chinese Medicine (TCM) helps to prevent the relapse of drug addiction. However, the scientific basis of TCM remains unclear because of limitations of current reductionist approaches. We aimed to explore the possible mechanism of how ANKK1 TaqIA (A1/A2) [rs1800497(T/C)] affects the relapse of opioid addiction on the perspective of Chinese traditional medicine....

“Reboot,” especially NoFap, promotes abstinence from masturbation and/or pornography to treat “pornography addiction,” an unrecognized diagnosis. While the intention of Reboot/NoFap is decrease distress, qualitative studies have consistently suggested that “Reboots” paradoxically cause more distress. The distress appears occur in response (1) goal, which recasts common sexual behaviors as perso...

Both pre-clinical and clinical studies make feasible the use of vaccines as novel therapeutic medications to treat drug addiction. No reports to date have shown the development of structural models of opiate candidate vaccines for treating human addiction to such compounds. Here we report on the initial development of a novel structural formulation of a bi-valent vaccine against morphine/heroin...

Addictive drugs remodel the brain's reward circuitry, the mesocorticolimbic dopamine (DA) system, by inducing widespread adaptations of glutamatergic synapses. This drug-induced synaptic plasticity is thought to contribute to both the development and the persistence of addiction. This review highlights the synaptic modifications that are induced by in vivo exposure to addictive drugs and descri...

Relapse to drug use is often cited as the major obstacle in overcoming a drug addiction. Whereas relapse can occur for a myriad of reasons, it is well established that complex neuroadaptations that occur over the course of addiction are major factors. Cocaine, as a potent dopamine transporter blocker, specifically induces alterations in the dopaminergic as well as other monoaminergic neurotrans...