The aryl hydrocarbon receptor (AhR) is targeted by ubiquitination for degradation by the proteasome shortly after its activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In silico screening identified p-anilinoaniline (pAA) as a putative inhibitor of an E2 ligase that partners with an E3 ligase implicated in AhR ubiquitination. We investigated whether pAA could modify AhR-dependent activa...

Since the addition of either ruminal fluid or a combination of phenylacetic and phenylpropionic acids (PAA/PPA) has previously been shown to dramatically improve cellulose degradation and growth of Ruminococcus albus, it was of interest to determine the effects of these additives on xylan-grown cultures. Although cell-bound xylanase activity increased when either PAA/PPA or ruminal fluid was ad...

The electrical and textural properties of single-walled carbon nanotube buckypapers were tunned through chemical functionalization processes. Single-walled carbon nanotubes (SWCNTs) were covalently functionalized with three different chemical groups: Carboxylic acids (-COOH), benzylamine (-Ph-CH2-NH2), and perfluorooctylaniline (-Ph-(CF2)7-CF3). Functionalized SWCNTs were dispersed in water or ...

Conventional studies of steroid hormone action proceed via quantitation of the maximal activity for gene induction at saturating concentrations of agonist steroid (i.e., A(max)). Less frequently analyzed parameters of receptor-mediated gene expression are EC(50) and PAA. The EC(50) is the concentration of steroid required for half-maximal agonist activity and is readily determined from the dose...

A series of dopant-type polyaniline-polyacrylic acid composite (PAn-PAA) films with porous structures were prepared and developed for an enzyme-free hydrogen peroxide (H(2)O(2)) sensor. The composite films were highly electroactive in a neutral environment as compared to polyaniline (PAn). In addition, the carboxyl group of the PAA was found to react with H(2)O(2) to form peroxy acid groups, an...

Previous reports have shown that nanoparticles (NPs) can both enhance and suppress immune effector functions; however the mechanisms that dictate these responses are still unclear. Here, the effects of polyacrylic acid (PAA) functionalized metal-oxide NP are investigated on RBL-2H3 (representative mammalian granulocyte-like cell line) cell viability, cellular degranulation, immunoglobulin E (Ig...

M in ne ap ol is , M N 5 54 47 VAPORIZED PERACETIC ACID (VPA) STERILIZATION Peracetic Acid as a Biocide REVOXTM sterilization technology uses a room temperature vapor composed of three active compounds; hydrogen peroxide (H2O2), acetic acid and peracetic acid (PAA). PAA is formed by the reaction of acetic acid and H2O2 with the addition of a catalyst; these compounds exist in equilibrium and th...

<p style='text-indent:20px;'>Pseudo almost automorphy (PAA) is a natural generalization of Bochner and Stepanov automorphy. Therefore, the results existence PAA solutions differential equations are few, pseudo automorphic difference rare. In this work, we concerned with model delayed cellular neural networks (CNNs). The delays considered in varying-time form. By Banach's fixed point theor...