The influence of 17beta-estradiol and 17alpha-estradiol on adult human omental adipocyte precursors grown in a propagating culture system was studied. Cells were grown in subculture in the presence or absence of hormone. 17beta-estradiol resulted in significant promotion of adipocyte precursor replication, as determined by cell counting and incorporation of radioactive thymidine into DNA. The h...

During adipose tissue development changes in lipoprotein lipase activity per adipocyte precede significant changes in fat cell size. Lipoprotein lipase activity per adipocyte increases fourfold from the second to seventh postnatal week. Furthermore, when isolated adipocytes and stromal--vascular cells are prepared by collagenase digestion of adipose tissue, there is a progressive shift in enzym...

Leptin has profound effects on adipose tissue metabolism. However, it remains unclear whether direct leptin signaling in adipocytes is involved. We addressed this question by transplanting inguinal adipose tissue stromal vascular cells (SVCs) from 4- to 5-wk-old wild-type (WT) and leptin receptor-deficient [Lepr(db/db) (db)] mice to inguinal and sternal subcutaneous sites in Ncr nude mice. Both...

results the results showed that children with a higher weight z-score spend more time in sedentary activities and less time running or involved in active games. scd-1 activity index, arachidonic/linoleic index, and adipocyte volume were significantly higher in children with a weight z-score greater than 0. the preadipocyte number and the genetic expression of the studied genes did not differ be...

Obesity is related to various diseases, such as diabetes, hyperlipidemia, and hypertension. Adipocytokine, which is released from adipocyte cells, affects insulin resistance and blood lipid level disorders. Further, adipocytokine is related to chronic inflammation in obesity condition adipocyte cells. Paprika pigments (PPs) contain large amounts of capsanthin and capsorubin. These carotenoids a...

BACKGROUND S-methylmethionine sulfonium chloride was originally called vitamin U because of its inhibition of ulceration in the digestive system. Vitamin U is ubiquitously expressed in the tissues of flowering plants, and while there have been reports on its hypolipidemic effect, its precise function remains unknown. OBJECTIVE This study was designed to evaluate the anti-obesity effect of vit...

1999, 19(8):5495. Mol. Cell. Biol. Michael Briggs, Bruce M. Spiegelman and Johan Auwerx Fruchart, Kim, Jamila Najib, Genevieve Martin, Jean-Charles Lluis Fajas, Kristina Schoonjans, Laurent Gelman, Jae B. and Metabolism Implications for Adipocyte Differentiation Regulatory Element Binding Protein 1: and Determination Factor 1/Sterol Expression by Adipocyte Differentiation γ Proliferator-Activat...

Obesity in both humans and rodents is characterized by adipocyte hypertrophy and the presence of death adipocytes surrounded by macrophages forming "crown-like structures." However, the biochemical pathways involved in triggering adipocyte death as well as the role of death adipocytes in adipose tissue remodeling and macrophage infiltration remain poorly understood. We now show that induction o...

OBJECTIVE Perivascular adipose tissue depots around the aorta are regionally distinct and have specific functional properties. Thoracic aorta perivascular adipose tissue (tPVAT) expresses higher levels of thermogenic genes and lower levels of inflammatory genes than abdominal aorta perivascular adipose tissue (aPVAT). It is not known whether this distinction is due to the in-vivo functional env...

Adipose tissue is a highly plastic organ that dynamically changes its size, cellular composition, and function in response to various nutritional hormonal changes. For instance, white adipose (WAT) can expand volume by 10 times under an obese state through hypertrophy (enlarged adipocyte size) hyperplasia (increased number), whereas it rapidly shrinks lipolysis upon fasting or cold exposure, th...