background: the cultured mesenchymal stem cells (msc) have been used in many clinical trials however, there are still some concerns about the cultural conditions. one concern is related to the use of fbs as a widely used xenogeneic supplement in the culture system. human platelet-rich plasma (hprp) is a candidate replacement for fbs. in this study, the effect of hprp on msc proliferation and os...

Adipose-derived stem cells are capable of differentiating into multiple cell types and thus considered useful for regenerative medicine. However, this differentiation feature seems to be associated with tumor initiation and metastasis raising safety concerns, which requires further investigation. In this study, we isolated adipose-derived stem cells from subcutaneous as well as from visceral ad...

in the last few years, a lot of preclinical studies showed the therapeutic potential of stem cells in spinal cord injury (sci). neural stem cells (nscs) can be differentiated into all cell types of spinal cord. nscs are cells that maintain the capacity to differentiate into brain-specific cell types, and may also replace or repair of injury in central nervous system. here in, we describe the ef...

introduction: dental pulp-derived mesenchymal stem cells (mscs) have emerged as a promising tool for use in regenerative medicine. the in vitro growth kinetic and culture requirement of the cells derived from human dental pulp, which is the subject of this present study, is poorly described. materials and methods: stem cells were derived from human third molar and then characterized. the in vit...

carpal chip fractures are common causes of lameness in racehorses. due to disadvantages in surgical management, adjuvant treatment modalities are usually necessary. adipose-derived stem cells (adscs) have the potential to differentiate into other cell types including bone and cartilage cells. adipose-derived stromal vascular fraction (svf) is produced during adscs isolation from adipose tissue....

Neuroinflammation has a significant role in induce of Multiple sclerosis (MS) many approaches have been used to treat MS, but none of these methods have not been able to fully improve. One of the methods can suppress inflammation and regenerate the nervous system is the use of cell therapy. Using cell therapy in pre-clinic phase can be realized, it's mechanism and potency to suppress neuroinfla...

Background Bone marrow and adipose tissue are two main sources of mesenchymal stem cells (MSCs). Some of studies suggest that there are some differences in gene expression profile of MSCs-derived from various tissues. To investigate gene expression profile by qRT-PCR, an appropriate reference gene with stable expression level should be chosen for normalizing data.  This study was designed to e...

background: recently, tissue engineering has developed approaches for repair and restoration of damaged skeletal system based on different scaffolds and cells. this study evaluated the ability of differentiated osteoblasts from adipose‑derived stem cells (adscs) seeded into hydroxyapatite/ tricalcium phosphate (ha‑tcp) to repair bone. methods: in this study, adscs of 6 canines were seeded in ha...

background: although cervical cancer mortality has reduced during last years, but it is still leading cause of mortality among women. many efforts have performed to develop new drugs and strategy to cure cervical cancer. mesenchymal stem cells (mscs) have many advantages that make them a suitable choice as a cell therapeutic agent in cancer treatment. there are different transfection methods fo...