ABE, K. AND HIROSE, T. Effect of Corticosterone and Cortisol on Corti costeroidogenesis in Isolated Rat Adrenal Cells. Tohoku J . exp. Med., 1974, 112 (2), 195-196 Isolated rat adrenal cells were incubated with corticosterone or cortisol in the presence of ACTH. When the corticosterone production in the absence of exogenous corticoids was taken as 100%, it was decreased to 77•}3 and 62•}4% by t...

The surgery of the adrenal gland is a subject which is expanding rapidly at the present time. Kendall's work on the identification of adrenal cortical hormones, leading in recent years to a plentiful supply of cortisone, has made such operations relatively safe. In addition, increased knowledge about the physiology of the gland has put this branch of surgery on a more rational basis. This artic...

The importance of the adrenal cortex in diabetes mellitus has been emphasized since the demonstration that the removal of the adrenals would lead to amelioration of diabetes in a depancreatectomized animal,) and that the administration of adrenal extract or hormones would produce an experimental diabetes.2) It is well known that the tumors or hyperplasia of the adrenal cortex are often associat...

It has been reported previously that the dermal spread of India ink with hyaluronidase is markedly influenced by the hormones of the adrenal cortex.'6' Removal of the adrenals resulted in an enhancement of the spreading reaction, while the administration of a potent extract of the adrenal cortex either in the adrenalectomized or normal animal inhibited spreading. However, desoxycorticosterone a...

The human adrenal cortex, involved in adaptive responses to stress, body homeostasis and secondary sexual characters, emerges from a tightly regulated development of a zone-specific secretion pattern during fetal life. Its development during fetal life is critical for the well being of pregnancy, the initiation of delivery, and even for an adequate adaptation to extra-uterine life. As early as ...

Orchiectomy in rats resulted in retarded body growth, and an increase in thymus and adrenal weights. With concomitant increase in adrenal cholesterol and corticosterone contents, adrenal norepinephrine, a minor component of medullary hormones, and the total catecholamine contents were also increassed by the operation. These changes were prevented or to be recovered by 2mg of testosterone propio...

A prolonged administration of glucocorticoids produces adrenal atrophy or hypofunction in man and experimental animals(Winter et al., 1950; Fraser et al., 1952; Lewis et al., 1953; Salassa et al., 1953; Dermatini et al., 1955; Bierich et al., 1959). This adrenal insufficiency has been attributed to a reduced ACTH secretion from the pituitary gland(Sayers and Sayers, 1950). For the prevention of...

It is well accepted from studies on adrenal cortical activity that stressful performance results in hypersecretion sometimes followed by hyposecretion. This physiological mainfestation has been called the "adaptation syndrome" (1). Along this line, two investigations were made to demonstrate the special diurnal rhythm in adrenal cortical activity of healthy men; in one of them 17-ketosteroid ou...

The isolated adrenal gland of the cow can be used in experiments devised to reveal correlations of cellular function mad structure. Structure may be studied by the electron microscope. Function in the adrenal cortex appears as the synthesis of adreuocorticoid hormones, which can be separated from the effluent perfusion fluid and identified and measured quantitativdy by column and paper chromato...