Vasoconstriction is one of the chief actions of adrenalin. The presence of minute quantities of it in the blood results in constriction of certain arterioles, especially those of the intestinal tract and those of the skin. A similar effect is produced at the site of injection into the tissues. This local effect is so intense as to interfere with the absorption of the drug itself or of admixed s...

BACKGROUND This study examined the effects of Palm vitamin E (PVE) and α-tocopherol (α-TF) supplementations on adrenalin, noradrenalin, xanthine oxidase plus dehydrogenase (XO + XD) activities and gastric lesions in rats exposed to water-immersion restraint stress (WIRS). METHODS Sixty male Sprague-Dawley rats (200-250 g) were randomly divided into three equal sized groups. The control group ...

During a recent investigation 1 by Dr. Stanton and myself of the lesions occurring in the aorta of the rabbit as the result of repeated injections of adrenalin, the heart muscle, in the few instances in which it was examined, was seen not infrequently to be the seat of very definite degenerative lesions and occasionally also of proliferative changes. The association of such conditions with an e...

BACKGROUND The male sex is a risk factor for reactive amyloidogenesis in several disease entities. Environmental, socioeconomic or genetic factors may underlie this male preponderance. This study was aimed at discovering whether male sex predisposes to reactive amyloidosis also in mice and to elucidate some of the hormonal associations of this risk. METHODS Male and female Swiss mice were sub...

WHILST fhe experimental results recorded in the two preceding studies were being. established, a parallel investigation was conducted clinically to establish Whether, the eye tolerates subconjunctival injections. of more ,than 50,000 units of crystalline penicillin and whether, the frequency of application could be reduced. The experimental result3 suggested that higher doses than 50,000 units ...

After Blum's discovery of the production of glycosuria by the subcutaneous injection of adrenal extract, Herter has the merit of having found that injection of adrenalin into the peritoneal cavity also produces glycosuria; this is an undeniable fact. Concerning Herter's claim that intraperitoneal injection gives a higher degree of glycosuria than subcutaneous or intravenous injection, we offer ...

The adrenochrome hypothesis of schizophrenia (Hoffer, Osmond and Smythies, 1954), was stimulated by the work of Osmond and Smythies (1952) which focused on methylated derivatives of adrenalin as possible endogenous schizophrenogens. They showed that the experience which followed the ingestion of mescaline was in many ways similar to the experience induced in normal people by schizophrenia. This...

The effect of cold and restraint on the level of non-protein sulfhydryl compounds in the liver and blood has been previously noted (l-4). Whether applied independently or together, these stresses result in a diminution of the total non-protein sulfhydryl concentration (NPSH) of the liver. Adrenalin (5) and certain anesthetics* produce an effect similar to that of cold and restraint. Grunert and...