Adrenaline is known to affect action potentials induced by the step current injection in an olfactory receptor cell (ORC). It is unclear, however, whether it also modulates action potentials induced by odor stimuli. In the present study, the effects of adrenaline on action potentials in ORCs were investigated quantitatively using a computer simulation. Adrenaline suppressed simulated action pot...

Four local anaesthetic solutions (2% carbonated lignocaine with or without adrenaline and 0.5% bupivacaine HCl with or without adrenaline) were used randomly for 335 continuous lumbar extradural blocks in labour. Carbonated lignocaine caused a more rapid onset of analgesia than bupivacaine HCl. The addition of adrenaline made little difference to the onset times, prolonged markedly the duration...

The effect of ACTH, adrenaline, noradrenaline, insulin, parathormone, hydrocortisone,and glucagonon the homeostaticmechanismcontrolling serum glucose,citrate, calcium, phosphorus,and potassium was studied in fasting rabbits and children. Citrate levelsare kept in balancebyACTH, adrenaline,and glucagon,which raisethe levels,and by insulin,which lowers them. Stressalone raisescitrate levels,proba...

INTRODUCTION AND BACKGROUND Adrenaline stimulates biphasic aggregation in plasma through the G(i) -coupled α(2A) -adrenoreceptor. In the present study, we demonstrate that both primary and secondary wave aggregation induced by adrenaline in plasma is blocked by two structurally distinct inhibitors of Src family kinases, dasatinib and PD0173952. METHODS AND RESULTS In contrast, primary aggrega...

Background Acute bronchiolitis is common cause of hospitalization in infants and young children. There are widespread variations in the diagnosis and management. Despite the use of bronchodilators for decades, there is lack of consensus for the benefit of one above another. Objective To compare initial response of nebulized adrenaline and salbutamol. Method Children aged two months to two years...

Adrenaline or UK 14304 (a specific a2-adrenoceptor agonist) and phorbol ester (phorbol 12,13-dibutyrate; PdBu) or bioactive diacylglycerols (sn1,2-dioctanoylglycerol; DiC8) synergistically induced platelet aggregation and ATP secretion. The effect on aggregation was more pronounced than the effect on secretion, and it was observed in aspirinized, platelet-rich plasma or suspensions of washed as...

Immediate survival among patients in cardiac arrest after three attempted direct current (DC) defibrillations for ventricular fibrillation (VF) or who are in asystole and receiving adequate cardiopulmonary resuscitation is less than 10%—the hospital discharge rate is less than 2%. Adrenaline is advocated to improve survival. The recommended dose of adrenaline is 1 mg bolus administered intraven...

1 The influence of thyroidectomy upon the adrenaline and noraddrenaline content of adrenal glands and plasma in mature female rats in pro-oestrus and in pregnant rats was studied. 2 Adrenal adrenaline and noradrenaline declined significantly after thyroidectomy in pro-oestrous and pregnant females but the effects were more marked in pregnant females. 3 Plasma adrenaline increased by 160% after ...

We present the results of a double-blind trial comparing the efficacy of a single dose combination of guanethidine 3 % and adrenaline 0 5 % with that of adrenaline 1 % alone in reducing the intraocular pressure of eyes suffering from chronic open-angle glaucoma. The mean fall in ocular tension with the combined therapy was 10-67 mmHg, and with adrenaline 1% 6-31 mmHg, 24 hours after the commenc...

In a short-term study, adrenaline-induced lipolysis was less in adrenalectomized rats than in controls, though the cyclic AMP accumulation was not different. In adrenalectomized rats treated with corticosterone, lipase activity was as low as in untreated adrenalectomized rats, although adrenaline-induced lipolysis was not reduced. In a long-term study, no reduction in adrenaline-induced lipolys...