نتایج جستجو برای: adrenergic agonist
تعداد نتایج: 85422 فیلتر نتایج به سال:
'H](±)Carazolol, " newly available ^-adrenergic receptor antagonist, has been used to characterize /f-adrenergic receptor subtypes present in membrane vesicles derived from canine ventricular myocardium and canine lung. [H](±)Carazolol binding is saturable, of high affinity, and in displaceable by /J-adi-e.nergic agents in accordance with their known pharmacological potencies. The interaction o...
The beta(2)-adrenergic receptor has been shown to display significant constitutive activity (i.e., in the absence of agonist) in addition to agonist-induced activation. Various studies have suggested that a movement in transmembrane helix VI plays a role in activation of various G-protein-coupled receptors. Here we show that a mutation in this domain of the beta(2)-adrenergic receptor abolishes...
BNST: bed nucleus of the stria terminalis; CRF: corticotropin releasing factor; VTA: ventral tegmental area Recommended journal section: Neuropharmacology This article has not been copyedited and formatted. The final version may differ from this version. ABSTRACT Stress can trigger relapse of drug use in recovering cocaine addicts and reinstatement in rodent models through mechanisms that appea...
Recent electrophysiological studies with cell membrane patches of cardiac myocytes and an electrically excitable cell line derived from rat pituitary tumor suggested that voltage activated calcium channels must be phosphorylated to respond to membrane depolarization (Armstrong and Eckert 1986; Trautwein and Kameyama 1986). In view of the "phosphorylation hypothesis" we investigated the adenylat...
Introduction: Malignant astrocytic gliomas are the most common and lethal brain malignancies due to their refractory to the current therapies. Nowadays, molecular targeted therapy has attracted great attention in treatment of glioma. Connexin 43 (Cx43) and micro ribonucleic acid- 21(miR-21) are among molecules that are involved in glioma development and progression. These molecules showed...
Intr The hemodynamic effects of laryngoscopy and endotracheal intubation are well known. A variety of drugs, like fentanyl, esmolol and lately dexmetomidine, have been used in order to attenuate the stress response to laryngoscopy and endotracheal intubation. Esmolol is an ultrashort acting beta 1 selective adrenergic antagonist, while dexmetomidine is an alpha 2 adrenergic receptor agonist. Fe...
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