The purpose of this manuscript is to describe a special interaction of the ethanol metabolite, acetaldehyde, with adrenergic systems. The term "adrenergic systems" is taken to comprise all catecholamine-containing nerve tracts, both in the central nervous system and in the peripheral sympathetic system; additionally, the adrenal medulla is included, as are certain of the clusters of interneuron...

The nuclear receptors “NR4As” productive pathway is the so important pathways for activating classic estrogen and are regulating adopted cellular anti-inflammatory growth(mediated by glucocorticoids, Nrf2, Ang2-AT2, VEGF-A synthesis) which considered as basic B-arrestins synthesis adopt B Adrenergic, Nrf2 synthesis, that strong activator to ACE functions promoting Ang2-AT2 running growth heme o...

Adrenergic regulation in sleep apnea is a complex process because adrenergic physiology is difficult to summarize with one measure. Furthermore, the role of the adrenergic system in sleep apnea is often confounded with hypertension, making interpretation difficult in hypertensive apneics. Sixty-six people with and without apnea and/or hypertension (all were off antihypertensive medication) part...

This review examines the impact of recent discoveries defining personal genetics of adrenergic signaling polymorphisms on scientific discovery and medical practice related to cardiovascular diseases. The adrenergic system is the major regulator of minute-by-minute cardiovascular function. Inhibition of adrenergic signaling with pharmacological beta-adrenergic receptor antagonists (beta-blockers...

OBJECTIVE Significant cardiac dysfunction after brain death leading to exclusion from procurement for cardiac transplantation is seen in up to 25% of potential organ donors in the absence of structural heart disease. The cause includes uncoupling of the myocardial beta-adrenergic receptor signaling system. The mechanism, however, has not yet been described. This study investigates our hypothesi...

• It is now established that the administration of reserpine or guanethidine is capable of preventing the response of effector organs to direct stimulation of post-ganglionic sympathetic nerves,even though the effector organ system remains responsive to the administration of the adrenergic transmitter, norepinephrine.' 3 Since both of these drugs have been shown to be capable of producing deple...

During stress, adrenergic signaling enhances cardiac conduction, although the mechanisms are not fully understood. Reducing extracellular calcium in heart widens an intercalated disc (ID) nanodomain adjacent to gap junctions known as perinexus. Under acute perinexus adaptively remodels; preventing this response by experimentally changing levels slows conduction and increases arrhythmia risk. Th...

The prognosis of patients with congestive heart failure (CHF) can be significantly improved with drug therapy targeted at the renin-angiotensin and adrenergic nervous system. beta-adrenergic blocking drugs, once contraindicated in CHF, have now been shown to improve survival in CHF.