The size and biomechanical properties of lipoproteins are tightly correlated with their structures/functions. While atomic force microscopy (AFM) has been used to image lipoproteins the force measurement of these nano-sized particles is missing. We detected that the sizes of LDL and HDL in liquid are close to the commonly known values. The Young's modulus of LDL or HDL is ∼0.4 GPa which is simi...

BACKGROUND Chitosan nanoparticles have become of great interest for nanomedicine, biomedical engineering and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. The aim of the present study was to synthesis and optimize of the chitosan nanoparticles for industrial and biomedical applicati...

Multifunctional carbon nanotubes are promising for biomedical applications as their nano-size, together with their physical stability, gives access into the cell and various cellular compartments including the nucleus. However, the direct and label-free detection of carbon nanotube uptake into cells is a challenging task. The atomic force microscope (AFM) is capable of resolving details of cell...

High-Resolution Imaging and Manipulation of Membrane Proteins by atomic force microscopy (AFM). Summary Membrane proteins are nanometric machines fulfilling defined functions in cell membranes. They work as transporters, linkers, adhesion molecules, channels, pumps, receptors, enzymes, and in the bio-energetic machineries, only naming a few tasks. In agreement with their importance, it was foun...

A comparative study of immature and mature bone marrow-derived dendritic cells (BMDCs) was first performed through an atomic force microscope (AFM) to clarify differences of their nanostructure and adhesion force. AFM images revealed that the immature BMDCs treated by granulocyte macrophage-colony stimulating factor plus IL-4 mainly appeared round with smooth surface, whereas the mature BMDCs i...

Nanorods hydroxyapatite, (HAP) Ca(10)(PO(4))(6)(OH)(2) is successfully prepared by water in oil microemulsion using, CaCL(2) and H(3)PO(4) (water phase), poly(sodium 4-styrene sulfonate) (PSSS) as template and cyclohexane as oil phase. The nano-structure of the product was studied by means of X-ray diffraction (XRD), Fourier transmission infrared spectrometer (FT-IR), scanning electron microsco...

The single-walled carbon-nanotube ~SWNT! was grown directly onto the top of the conventional Si atomic force microscopy ~AFM! cantilever. This SWNT AFM cantilever was introduced into the AFM nano-oxidation process, which oxidized the titanium ~Ti! metal film on the atomically flat a-Al2O3 substrate and formed the ultranarrow oxidized titanium (TiOx) line of 5 nm width. This TiOx line was used a...

background: chitosan nanoparticles have become of great interest for nanomedicine, biomedical engineering and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. the aim of the present study is to synthesis and optimization of chitosan nanoparticles for industrial and biomedical applicati...

The introduction of atomic force microscopy (AFM) techniques has revolutionised our ability to characterise colloidal objects. AFM allows the visualisation of samples with sub-nanometre resolution in three dimensions in atmospheric or submerged conditions. Nanomedical research is increasingly focused on the design, characterisation and delivery of nano-sized drug carriers such as nanoparticles,...

Atomic force microscopy (AFM) was used for visualization of a nano-oxidation technique performed on diamond-like carbon (DLC) thin film. Experiments of the nano-oxidation technique of the DLC thin film include those on nano-oxidation points and nano-oxidation lines. The feature sizes of the DLC thin film, including surface morphology, depth, and width, were explored after application of a nano-...